Synthetic progestogens (progestins) have been linked to increased breast cancer risk;
however, the role of endogenous progesterone in breast physiology and carcinogenesis is …

Progesterone receptor (PR) is a master regulator in female reproductive tissues that controls
developmental processes and proliferation and differentiation during the reproductive cycle …

During the implantation window, the endometrium becomes poised to transition to a
pregnant state, a process driven by differentiation of stromal cells into decidual cells (DC) …

Steroid hormone receptors (SRs) have a multitude of functions in human biology and
disease progression. The SR family of related ligand-activated transcription factors includes …

Background Estrogen and progesterone are potent breast mitogens. In addition to steroid
hormones, multiple signaling pathways input to estrogen receptor (ER) and progesterone …

Ovarian cancer (OC) represents a collection of rare but lethal gynecologic cancers where
the difficulty of early detection due to an often-subtle range of abdominal symptoms …

Simple Summary Endocrine therapy is a common treatment for estrogen-responsive breast
cancer, which is used to block the tumor growth-promoting effect of this hormone. The …

Steroid hormone receptors (SRs) are classically defined as ligand-activated transcription
factors that function as master regulators of gene programs important for a wide range of …

Progesterone receptors (PRs) are key modifiers of estrogen receptor (ER) target genes and
drivers of luminal breast cancer progression. Total PR expression, rather than isoform …

Major roadblocks to developing effective progesterone receptor (PR)-targeted therapies in
breast cancer include the lack of highly-specific PR modulators, a poor understanding of the …