The plasma membrane of eukaryotic cells is not a simple sheet of lipids and proteins but is
differentiated into subdomains with crucial functions. Caveolae, small pits in the plasma …

Caveolae are submicroscopic, plasma membrane pits that are abundant in many
mammalian cell types. The past few years have seen a quantum leap in our understanding …

The plasma membrane in eukaryotic cells contains microdomains that are enriched in
certain glycosphingolipids, gangliosides, and sterols (such as cholesterol) to form …

Aging causes many changes in the human body, and is a high risk for various diseases.
Dementia, a common age-related disease, is a clinical disorder triggered by …

Cholesterol is an important constituent of cell membranes and plays a crucial role in the
compartmentalization of the plasma membrane and signaling. Brain cholesterol accounts for …

Cholesterol is a critical component of membrane bilayers where it plays key structural and
functional roles by regulating the activity of diverse signaling platforms and pathways …

A better understanding of the cellular physiological role that plasma membrane lipids, fatty
acids and sterols play in various cellular systems may yield more insight into how cellular …

Osteoarthritis is the most common musculoskeletal disease causing chronic disability in
adults. Studying cartilage aging, chondrocyte senescence, inflammation, and autophagy …

It is estimated that in 2017 there were 451 million people with diabetes worldwide. These
figures are expected to increase to 693 million by 2045; thus, innovative preventative …

The synapse is a crowded area. In the last years, the concept that proteins can be organized
in different membrane domains according to their structure has emerged. Cholesterol-rich …