Structure, function, and pharmacology of glutamate receptor ion channels
Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
Illuminating dendritic function with computational models
P Poirazi, A Papoutsi - Nature reviews neuroscience, 2020 - nature.com
Dendrites have always fascinated researchers: from the artistic drawings by Ramon y Cajal
to the beautiful recordings of today, neuroscientists have been striving to unravel the …
to the beautiful recordings of today, neuroscientists have been striving to unravel the …
Hyperpolarization-activated cation channels: from genes to function
M Biel, C Wahl-Schott, S Michalakis… - Physiological …, 2009 - journals.physiology.org
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels comprise a small
subfamily of proteins within the superfamily of pore-loop cation channels. In mammals, the …
subfamily of proteins within the superfamily of pore-loop cation channels. In mammals, the …
Pyramidal neurons: dendritic structure and synaptic integration
N Spruston - Nature Reviews Neuroscience, 2008 - nature.com
Pyramidal neurons are characterized by their distinct apical and basal dendritic trees and
the pyramidal shape of their soma. They are found in several regions of the CNS and …
the pyramidal shape of their soma. They are found in several regions of the CNS and …
[图书][B] The hippocampus book
The hippocampus is one of a group of remarkable structures embedded within the brain's
medial temporal lobe. Long known to be important for memory, it has been a prime focus of …
medial temporal lobe. Long known to be important for memory, it has been a prime focus of …
The geometric structure of the brain fiber pathways
VJ Wedeen, DL Rosene, R Wang, G Dai, F Mortazavi… - Science, 2012 - science.org
The structure of the brain as a product of morphogenesis is difficult to reconcile with the
observed complexity of cerebral connectivity. We therefore analyzed relationships of …
observed complexity of cerebral connectivity. We therefore analyzed relationships of …
The high-conductance state of neocortical neurons in vivo
Intracellular recordings in vivo have shown that neocortical neurons are subjected to an
intense synaptic bombardment in intact networks and are in a'high-conductance'state. In …
intense synaptic bombardment in intact networks and are in a'high-conductance'state. In …
Dendritic structural degeneration is functionally linked to cellular hyperexcitability in a mouse model of Alzheimer's disease
Z Šišková, D Justus, H Kaneko, D Friedrichs… - Neuron, 2014 - cell.com
Dendritic structure critically determines the electrical properties of neurons and, thereby,
defines the fundamental process of input-to-output conversion. The diversity of dendritic …
defines the fundamental process of input-to-output conversion. The diversity of dendritic …
Pyramidal neuron as two-layer neural network
The pyramidal neuron is the principal cell type in the mammalian forebrain, but its function
remains poorly understood. Using a detailed compartmental model of a hippocampal CA1 …
remains poorly understood. Using a detailed compartmental model of a hippocampal CA1 …
Computational subunits in thin dendrites of pyramidal cells
The thin basal and oblique dendrites of cortical pyramidal neurons receive most of the
synaptic inputs from other cells, but their integrative properties remain uncertain. Previous …
synaptic inputs from other cells, but their integrative properties remain uncertain. Previous …