Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Dendrites have always fascinated researchers: from the artistic drawings by Ramon y Cajal
to the beautiful recordings of today, neuroscientists have been striving to unravel the …

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels comprise a small
subfamily of proteins within the superfamily of pore-loop cation channels. In mammals, the …

Pyramidal neurons are characterized by their distinct apical and basal dendritic trees and
the pyramidal shape of their soma. They are found in several regions of the CNS and …

The hippocampus is one of a group of remarkable structures embedded within the brain's
medial temporal lobe. Long known to be important for memory, it has been a prime focus of …

The structure of the brain as a product of morphogenesis is difficult to reconcile with the
observed complexity of cerebral connectivity. We therefore analyzed relationships of …

Intracellular recordings in vivo have shown that neocortical neurons are subjected to an
intense synaptic bombardment in intact networks and are in a'high-conductance'state. In …

Dendritic structure critically determines the electrical properties of neurons and, thereby,
defines the fundamental process of input-to-output conversion. The diversity of dendritic …

The pyramidal neuron is the principal cell type in the mammalian forebrain, but its function
remains poorly understood. Using a detailed compartmental model of a hippocampal CA1 …

The thin basal and oblique dendrites of cortical pyramidal neurons receive most of the
synaptic inputs from other cells, but their integrative properties remain uncertain. Previous …