Biocatalysis has an enormous impact on chemical synthesis. The waves in which
biocatalysis has developed, and in doing so changed our perception of what organic …

As a result of the adaptation of life to an aerobic environment, nature has evolved a panoply
of metalloproteins for oxidative metabolism and protection against reactive oxygen species …

Peroxynitrite is a short-lived and reactive biological oxidant formed from the diffusion-
controlled reaction of the free radicals superoxide (O2•–) and nitric oxide (• NO). In this …

Direct C–H bond functionalization catalyzed by non-precious transition metals is an
attractive strategy in synthetic chemistry. Compared with the precious metals rhodium …

Biocatalysis over the past few years has matured into an essential tool for modern, cost
effective and sustainable pharmaceutical manufacturing. While some reaction classes are …

Copper is one of the most abundant and less toxic transition metals. Nature takes advantage
of the bioavailability and rich redox chemistry of Cu to carry out oxygenase and oxidase …

Highlights•Cytochrome P450 enzymes catalyse oxygen insertion into a wide range of
substrates.•Mutagenesis of P450s frequently allows novel substrate recognition.•P450s …

Cytochromes P450 (CYPs) belong to the superfamily of heme b containing
monooxygenases with currently more than 21,000 members. These enzymes accept a vast …

Cytochrome P450 enzymes primarily catalyze mixed-function oxidation reactions, plus some
reductions and rearrangements of oxygenated species, eg prostaglandins. Most of these …

Covering: 2000 up to 2018 The cytochromes P450 (P450s) are a superfamily of heme-
containing monooxygenases that perform diverse catalytic roles in many species, including …