The epithelial-mesenchymal transition (EMT) represents a biological program during which
epithelial cells lose their cell identity and acquire a mesenchymal phenotype. EMT is …

Carotenoids are natural pigments that play pivotal roles in many physiological functions. The
characteristics of carotenoids, their effects on health, and the cosmetic benefits of their …

Brown and beige adipocytes expend chemical energy to produce heat and are therefore
important in regulating body temperature and body weight. Brown adipocytes develop in …

Since brown adipose tissue (BAT) dissipates energy through UCP1, BAT has garnered
attention as a therapeutic intervention for obesity and metabolic diseases including type 2 …

While most tissues exhibit their greatest growth during development, adipose tissue is
capable of additional massive expansion in adults. Adipose tissue expandability is …

Adipose tissue, best known for its role in fat storage, can also suppress weight gain and
metabolic disease through the action of specialized, heat-producing adipocytes. Brown …

Accumulation of excess white adipose tissue (WAT) has deleterious consequences for
metabolic health. The activation of brown adipose tissue (BAT), the primary organ for heat …

Exercise training benefits many organ systems and offers protection against metabolic
disorders such as obesity and diabetes. Using the recently identified isoform of PGC1-α …

Chronic overnutrition and obesity induces low-grade inflammation throughout the body.
Termed “meta-inflammation,” this chronic state of inflammation is mediated by macrophages …

Exercise benefits a variety of organ systems in mammals, and some of the best-recognized
effects of exercise on muscle are mediated by the transcriptional co-activator PPAR-γ co …