Cisplatin is a chemotherapeutic agent that is widely used to treat a variety of malignant
tumors. Serious dose-limiting side effects like ototoxicity, nephrotoxicity and neurotoxicity …

Recent studies indicate that, in addition to necrosis, apoptosis also plays a role in the
process of tissue damage after myocardial infarction, which has pathological and …

Proteins of the interleukin-6 (IL-6) family bind to receptors in the plasma membrane.
Subsequent signal transduction involves activation of the janus kinase (JAK) and signal …

The seven members of the signal transducer and activator of transcription (STAT) family of
transcription factors are activated in response to many different cytokines and growth factors …

Over the last two decades, it has become increasingly clear that reactive oxygen species
(ROS), including free radicals are involved in cardiovascular disease. In recent years, there …

Signal transducers and activators of transcription (STATs) are latent cytoplasmic
transcription factors that mediate various biological responses, including cell proliferation …

Stat1 is phosphorylated on serine 727 within its transactivating domain (TAD) in response to
interferons or other immunological signals. We generated gene-targeted mutant mice …

Fas is a widely expressed cell surface receptor that can initiate apoptosis when activated by
its ligand (FasL). Whereas Fas abundance on cardiac myocytes increases in response to …

Abstract p38 kinases are members of the mitogen-activated protein kinases (MAPK) with
established contribution to a wide range of signaling pathways and different biological …

The STAT-1 transcription factor has been implicated as a tumor suppressor by virtue of its
ability to inhibit cell growth and promoting apoptosis. However, the mechanisms by which …