RNA adopts 3D structures that confer varied functional roles in human biology and
dysfunction in disease. Approaches to therapeutically target RNA structures with small …

With both catalytic and genetic functions, ribonucleic acid (RNA) is perhaps the most
pluripotent chemical species in molecular biology, and its functions are intimately linked to …

S-Adenosyl-l-methionine (SAM)-responsive riboswitches play a central role in the regulation
of bacterial gene expression at the level of transcription attenuation or translation inhibition …

Noncoding RNAs (ncRNAs) accomplish a remarkable variety of biological functions. They
regulate gene expression at the levels of transcription, RNA processing, and translation …

Riboswitches were discovered in 2002 in bacteria as RNA-based intracellular sensors of
vitamin derivatives. During the last decade, naturally occurring RNA sensor elements have …

Molecular dynamics (MD) simulation has become a powerful tool for characterizing at an
atomic level of detail the conformational changes undergone by proteins. The application of …

Riboswitches are structural RNA elements that are generally located in the 5′ untranslated
region of messenger RNA. During regulation of gene expression, ligand binding to the …

Genetically encoded sensors are powerful tools for imaging intracellular metabolites and
signaling molecules. However, developing sensors is challenging because they require …

GFP and its derivatives revolutionized the study of proteins. Spinach is a recently reported in
vitro–evolved RNA mimic of GFP, which as genetically encoded fusions makes possible live …

An expanding number of metabolite-binding riboswitch classes are being discovered in the
noncoding portions of bacterial genomes. Findings over the last decade indicate that …