[HTML][HTML] A multi‐organ analysis of the role of mTOR in fetal alcohol spectrum disorders

AL Carabulea, JD Janeski, VD Naik, K Chen… - The FASEB …, 2023 - ncbi.nlm.nih.gov
Alcohol exposure during gestation can lead to fetal alcohol spectrum disorders (FASD), an
array of cognitive and physical developmental impairments. Over the past two and a half …

[HTML][HTML] Alcohol exposure suppresses ribosome biogenesis and causes nucleolar stress in cranial neural crest cells

GR Flentke, TE Wilkie, J Baulch, Y Huang, SM Smith - PLoS One, 2024 - journals.plos.org
Prenatal alcohol exposure (PAE) causes cognitive impairment and a distinctive craniofacial
dysmorphology, due in part to apoptotic losses of the pluripotent cranial neural crest cells …

[HTML][HTML] Binge-like prenatal ethanol exposure causes impaired cellular differentiation in the embryonic forebrain and synaptic and behavioral defects in adult mice

S Subbanna, BS Basavarajappa - Brain Sciences, 2022 - mdpi.com
An embryo's in-utero exposure to ethanol due to a mother's alcohol drinking results in a
range of deficits in the child that are collectively termed fetal alcohol spectrum disorders …

[HTML][HTML] Dose-related shifts in proteome and function of extracellular vesicles secreted by fetal neural stem cells following chronic alcohol exposure

DD Chung, MR Pinson, AH Mahnke, NA Salem, KT Le… - Heliyon, 2022 - cell.com
Accumulating evidence indicates that extracellular vesicles (EVs) mediate endocrine
functions and also pathogenic effects of neurodevelopmental perturbagens like ethanol. We …

[HTML][HTML] Rapamycin improves recognition memory and normalizes amino-acids and amines levels in the hippocampal dentate gyrus in adult rats exposed to ethanol …

M Lopatynska-Mazurek, A Pankowska… - Biomolecules, 2021 - mdpi.com
The mammalian target of rapamycin (mTOR), a serine/threonine kinase, is implicated in
synaptic plasticity by controlling protein synthesis. Research suggests that ethanol exposure …

Antidepressant-like effect of CP-101,606: Evidence of mTOR pathway activation

Y Qin, X Guo, W Song, Z Liang, Y Wang, D Feng… - Molecular and Cellular …, 2023 - Elsevier
Background As a non-competitive N-methyl d-aspartate receptor antagonist, ketamine exerts
rapid-onset and long-lasting antidepressant effects on depression, but some side effects …

[HTML][HTML] Rapamycin improves spatial learning deficits, vulnerability to alcohol addiction and altered expression of the GluN2B subunit of the NMDA receptor in adult …

M Lopatynska-Mazurek, A Antolak, P Grochecki… - Biomolecules, 2021 - mdpi.com
Ethanol exposure during pregnancy alters the mammalian target of rapamycin (mTOR)
signaling pathway in the fetal brain. Hence, in adult rats exposed to ethanol during the …

[HTML][HTML] Alcohol Dependence Modulates Amygdalar mTORC2 and PKCε Expression in a Rodent Model

A Hanim, IN Mohamed, RMP Mohamed, MH Mokhtar… - Nutrients, 2023 - mdpi.com
Multiple alcohol use disorder (AUD)-related behavioral alterations are governed by protein
kinase C epsilon (PKCε), particularly in the amygdala. Protein kinase C (PKC) is readily …

Morphological alteration in rat hippocampal neuronal dendrites following chronic binge prenatal alcohol exposure

J Lee, V Naik, M Orzabal, R Lunde-Young… - Brain research, 2021 - Elsevier
Prenatal alcohol exposure (PAE) may result in Fetal Alcohol Spectrum Disorders (FASD).
The hippocampus has been recognized as a vulnerable target to alcohol-induced …

[HTML][HTML] In Vivo Administration of Phosphatidic Acid, a Direct Alcohol Target Rescues Fetal Growth Restriction and Maternal Uterine Artery Dysfunction in Rat FASD …

JD Janeski, VD Naik, AL Carabulea, H Jiang… - Nutrients, 2024 - mdpi.com
Fetal growth restriction is a hallmark of Fetal Alcohol Syndrome (FAS) and is accompanied
by maternal uterine circulatory maladaptation. FAS is the most severe form of Fetal Alcohol …