[HTML][HTML] A multi‐organ analysis of the role of mTOR in fetal alcohol spectrum disorders
Alcohol exposure during gestation can lead to fetal alcohol spectrum disorders (FASD), an
array of cognitive and physical developmental impairments. Over the past two and a half …
array of cognitive and physical developmental impairments. Over the past two and a half …
[HTML][HTML] Alcohol exposure suppresses ribosome biogenesis and causes nucleolar stress in cranial neural crest cells
GR Flentke, TE Wilkie, J Baulch, Y Huang, SM Smith - PLoS One, 2024 - journals.plos.org
Prenatal alcohol exposure (PAE) causes cognitive impairment and a distinctive craniofacial
dysmorphology, due in part to apoptotic losses of the pluripotent cranial neural crest cells …
dysmorphology, due in part to apoptotic losses of the pluripotent cranial neural crest cells …
[HTML][HTML] Binge-like prenatal ethanol exposure causes impaired cellular differentiation in the embryonic forebrain and synaptic and behavioral defects in adult mice
S Subbanna, BS Basavarajappa - Brain Sciences, 2022 - mdpi.com
An embryo's in-utero exposure to ethanol due to a mother's alcohol drinking results in a
range of deficits in the child that are collectively termed fetal alcohol spectrum disorders …
range of deficits in the child that are collectively termed fetal alcohol spectrum disorders …
[HTML][HTML] Dose-related shifts in proteome and function of extracellular vesicles secreted by fetal neural stem cells following chronic alcohol exposure
Accumulating evidence indicates that extracellular vesicles (EVs) mediate endocrine
functions and also pathogenic effects of neurodevelopmental perturbagens like ethanol. We …
functions and also pathogenic effects of neurodevelopmental perturbagens like ethanol. We …
[HTML][HTML] Rapamycin improves recognition memory and normalizes amino-acids and amines levels in the hippocampal dentate gyrus in adult rats exposed to ethanol …
M Lopatynska-Mazurek, A Pankowska… - Biomolecules, 2021 - mdpi.com
The mammalian target of rapamycin (mTOR), a serine/threonine kinase, is implicated in
synaptic plasticity by controlling protein synthesis. Research suggests that ethanol exposure …
synaptic plasticity by controlling protein synthesis. Research suggests that ethanol exposure …
Antidepressant-like effect of CP-101,606: Evidence of mTOR pathway activation
Y Qin, X Guo, W Song, Z Liang, Y Wang, D Feng… - Molecular and Cellular …, 2023 - Elsevier
Background As a non-competitive N-methyl d-aspartate receptor antagonist, ketamine exerts
rapid-onset and long-lasting antidepressant effects on depression, but some side effects …
rapid-onset and long-lasting antidepressant effects on depression, but some side effects …
[HTML][HTML] Rapamycin improves spatial learning deficits, vulnerability to alcohol addiction and altered expression of the GluN2B subunit of the NMDA receptor in adult …
M Lopatynska-Mazurek, A Antolak, P Grochecki… - Biomolecules, 2021 - mdpi.com
Ethanol exposure during pregnancy alters the mammalian target of rapamycin (mTOR)
signaling pathway in the fetal brain. Hence, in adult rats exposed to ethanol during the …
signaling pathway in the fetal brain. Hence, in adult rats exposed to ethanol during the …
[HTML][HTML] Alcohol Dependence Modulates Amygdalar mTORC2 and PKCε Expression in a Rodent Model
A Hanim, IN Mohamed, RMP Mohamed, MH Mokhtar… - Nutrients, 2023 - mdpi.com
Multiple alcohol use disorder (AUD)-related behavioral alterations are governed by protein
kinase C epsilon (PKCε), particularly in the amygdala. Protein kinase C (PKC) is readily …
kinase C epsilon (PKCε), particularly in the amygdala. Protein kinase C (PKC) is readily …
Morphological alteration in rat hippocampal neuronal dendrites following chronic binge prenatal alcohol exposure
Prenatal alcohol exposure (PAE) may result in Fetal Alcohol Spectrum Disorders (FASD).
The hippocampus has been recognized as a vulnerable target to alcohol-induced …
The hippocampus has been recognized as a vulnerable target to alcohol-induced …
[HTML][HTML] In Vivo Administration of Phosphatidic Acid, a Direct Alcohol Target Rescues Fetal Growth Restriction and Maternal Uterine Artery Dysfunction in Rat FASD …
JD Janeski, VD Naik, AL Carabulea, H Jiang… - Nutrients, 2024 - mdpi.com
Fetal growth restriction is a hallmark of Fetal Alcohol Syndrome (FAS) and is accompanied
by maternal uterine circulatory maladaptation. FAS is the most severe form of Fetal Alcohol …
by maternal uterine circulatory maladaptation. FAS is the most severe form of Fetal Alcohol …