The ribosome is a multi-unit complex that translates mRNA into protein. Ribosome
biogenesis is the process that generates ribosomes and plays an essential role in cell …

Despite several decades of intense research focused on understanding function (s) and
disease-associated malfunction of p53, there is no sign of any “mid-life crisis” in this rapidly …

Targeting nucleotide metabolism can not only inhibit tumor initiation and progression but
also exert serious side effects. With in-depth studies of nucleotide metabolism, our …

Nucleotide metabolism supports RNA synthesis and DNA replication to enable cell growth
and division. Nucleotide depletion can inhibit cell growth and proliferation, but how cells …

Simple Summary Cells need to produce ribosomes to sustain continuous proliferation and
expand in numbers, a feature that is even more prominent in uncontrollably proliferating …

Ribosome biogenesis (RiBi) is one of the most complex and energy demanding processes
in human cells, critical for cell growth and proliferation. Strong causal links between …

Nuclear metabolism and DNA damage response are intertwined processes, but the precise
molecular links remain elusive. Here, we explore this crosstalk using triple-negative breast …

The human ribosomes are the cellular machines that participate in protein synthesis, which
is deeply affected during cancer transformation by different oncoproteins and is shown to …

Ribosomal proteins (Rps) are essential for viability. Genetic mutations affecting Rp genes
were first discovered in Drosophila, where they represent a major class of haploinsufficient …

DNA damage and genome instability in host cells are introduced by many viruses during
their life cycles. Severe acute respiratory syndrome coronaviruses (SARS-CoVs) …