Precision medicine relies on validated biomarkers with which to better classify patients by
their probable disease risk, prognosis and/or response to treatment. Although …

Lung cancer is the leading cause of cancer-related mortality worldwide. Advances in our
understanding of the genomics of lung cancer have led to substantial progress in the …

Lung cancer is the leading cause of cancer death in men and women worldwide. The lack of
specific and sensitive tools for early diagnosis as well as still-inadequate targeted therapies …

Rationale: Subsets of patients with early-stage lung adenocarcinoma (LUAD) have a poor
post-surgical course after curative surgery. However, biomarkers stratifying this high-risk …

Differential expression (DE) is commonly used to explore molecular mechanisms of
biological conditions. While many studies report significant results between their groups of …

Findings from clinical and biological studies are often not reproducible when tested in
independent cohorts. Due to the testing of a large number of hypotheses and relatively small …

Epigenetic research has the potential to improve our understanding of the pathogenesis of
cancer, specifically non-small-cell lung cancer, and support our efforts to personalize the …

Background: N6-methyladenosine (m 6 A) RNA methylation is dynamically and reversibly
regulated by methyl-transferases (" writers"), binding proteins (" readers"), and demethylases …

Background Smoking leads to the aging of organs. However, no studies have been
conducted to quantify the effect of smoking on the aging of respiratory organs and the aging …

Synchronous liver metastasis (SLM) remains a major challenge for rectal cancer. Early
detection of SLM is a key factor to improve the survival rate of rectal cancer. In this radiomics …