Understanding the impacts of bacteriophage viruses: from laboratory evolution to natural ecosystems

B Koskella, CA Hernandez… - Annual Review of …, 2022 - annualreviews.org
Viruses of bacteria (bacteriophages or phage) have broad effects on bacterial ecology and
evolution in nature that mediate microbial interactions, shape bacterial diversity, and …

Coevolution between bacterial CRISPR-Cas systems and their bacteriophages

BNJ Watson, JA Steens, RHJ Staals, ER Westra… - Cell host & …, 2021 - cell.com
CRISPR-Cas systems provide bacteria and archaea with adaptive, heritable immunity
against their viruses (bacteriophages and phages) and other parasitic genetic elements …

Phage anti-CRISPR control by an RNA-and DNA-binding helix–turn–helix protein

N Birkholz, K Kamata, M Feussner, ME Wilkinson… - Nature, 2024 - nature.com
In all organisms, regulation of gene expression must be adjusted to meet cellular
requirements and frequently involves helix–turn–helix (HTH) domain proteins. For instance …

A diverse repertoire of anti-defense systems is encoded in the leading region of plasmids

B Samuel, D Burstein - bioRxiv, 2023 - biorxiv.org
Plasmids are an important source of antibiotic-resistance genes that mobilize horizontally
between bacteria, including many human pathogens. Bacteria express various defense …

The never-ending battle between lactic acid bacteria and their phages

C Philippe, JK Cornuault, AG de Melo… - FEMS Microbiology …, 2023 - academic.oup.com
Over the past few decades, the interest in lactic acid bacteria (LAB) has been steadily
growing. This is mainly due to their industrial use, their health benefits as probiotic bacteria …

Transient eco-evolutionary dynamics early in a phage epidemic have strong and lasting impact on the long-term evolution of bacterial defences

BNJ Watson, E Pursey, S Gandon, ER Westra - Plos Biology, 2023 - journals.plos.org
Organisms have evolved a range of constitutive (always active) and inducible (elicited by
parasites) defence mechanisms, but we have limited understanding of what drives the …

CRISPR-Cas in Pseudomonas aeruginosa provides transient population-level immunity against high phage exposures

BNJ Watson, L Capria, EO Alseth, BJ Pons… - The ISME …, 2024 - academic.oup.com
The prokaryotic adaptive immune system, CRISPR-Cas (clustered regularly interspaced
short palindromic repeats; CRISPR-associated), requires the acquisition of spacer …

Polyamines and linear DNA mediate bacterial threat assessment of bacteriophage infection

CD de Mattos, DR Faith, AA Nemudryi… - Proceedings of the …, 2023 - National Acad Sciences
Monitoring the extracellular environment for danger signals is a critical aspect of cellular
survival. However, the danger signals released by dying bacteria and the mechanisms …

Fitness costs of CRISPR-Cas systems in bacteria

M Zaayman, RM Wheatley - Microbiology, 2022 - microbiologyresearch.org
CRISPR-Cas systems provide bacteria with both specificity and adaptability in defence
against invading genetic elements. From a theoretical perspective, CRISPR-Cas systems …

The effect of Quorum sensing inhibitors on the evolution of CRISPR-based phage immunity in Pseudomonas aeruginosa

JM Broniewski, MAW Chisnall… - The ISME …, 2021 - academic.oup.com
Quorum sensing controls the expression of a wide range of important traits in the
opportunistic pathogen Pseudomonas aeruginosa, including the expression of virulence …