The human skeleton undergoes constant remodeling throughout the lifetime. Processes
occurring on microscopic and molecular scales degrade bone and replace it with new, fully …

Until recently many studies of bone remodeling at the cellular level have focused on the
behavior of mature osteoblasts and osteoclasts, and their respective precursor cells, with the …

Bone remodelling maintains the functionality of skeletal tissue by locally coordinating bone-
resorbing cells (osteoclasts) and bone-forming cells (osteoblasts) in the form of Bone …

The human skeleton has a remarkable regeneration capacity. Nevertheless, 5–10% of the
bone fractures fails to heal and develops into a non-union which is a challenging orthopedic …

Bone is a common site for cancer metastasis. To create space for their growth, cancer cells
stimulate bone resorbing osteoclasts. Cytokine RANKL is a key osteoclast activator, while …

Cortical bone remodeling is carried out by basic multicellular units (BMUs), which couple
resorption to formation. Although fluorochrome labeling has facilitated study of BMU …

Age‐related bone loss and postmenopausal osteoporosis are due to a dysregulation of
bone remodelling in which less bone is reformed than resorbed. This dysregulation of bone …

Bone remodeling is an essential, delicately balanced physiological process of coordinated
activity of bone cells that remove and deposit new bone tissue in the adult skeleton. Due to …

Bone remodelling is carried out by 'bone multicellular units'(BMU s) in which active
osteoclasts and active osteoblasts are spatially and temporally coupled. The refilling of new …

We propose a finite element formulation for a coupled elasticity–reaction–diffusion system
written in a fully Lagrangian form and governing the spatio-temporal interaction of species …