Biofabricated tissues have found numerous applications in tissue engineering and
regenerative medicine in addition to the promotion of disease modeling and drug …

A cell spheroid is a three-dimensional (3D) aggregation of cells. Synthetic, in-vitro spheroids
provide similar metabolism, proliferation, and species concentration gradients to those found …

“Organ‐on‐a‐chip” systems integrate microengineering, microfluidic technologies, and
biomimetic principles to create key aspects of living organs faithfully, including critical …

Novel microfluidic tools allow new ways to manufacture and test drug delivery systems.
Organ-on-a-chip systems—microscale recapitulations of complex organ functions—promise …

For decades, scientists have been using two-dimensional cell culture platforms for high-
throughput drug screening of anticancer drugs. Growing evidence indicates that the results …

Microsensor systems for cell metabolism are essential tools for investigation and
standardization in cell culture. Electrochemical and optical read-out schemes dominate …

There is increasing interest in utilizing in vitro cultures as patient avatars to develop
personalized treatment for cancer. Typical cultures utilize Matrigel-coated plates and media …

Introduction: The development of emerging in vitro tissue culture platforms can be useful for
predicting human response to new compounds, which has been traditionally challenging in …

The development of novel cellular models that can replace animals in preclinical trials of
drug candidates is one of the major goals of cell engineering. Current in vitro screening …

Anti-cancer drug development is inefficient, mostly due to lack of efficacy in human patients.
The high fail rate is partly due to the lack of predictive models or the inadequate use of …