The development of fluorochrome‐conjugated peptide–major histocompatibility complex
(pMHC) multimers in conjunction with continuing advances in flow cytometry has …

T cells initiate and regulate adaptive immune responses that can clear infections. To do this,
they use their T cell receptors (TCR s) to continually scan the surfaces of other cells for …

Here, we report on the expression of programmed death (PD)-1 on human virus-specific
CD8+ T cells and the effect of manipulating signaling through PD-1 on the survival …

Lymph nodes (LNs) are critical sites for shaping tissue-specific adaptive immunity. However,
the impact of LN sharing between multiple organs on such tailoring is less understood. Here …

Peptides derived from almost all proteins, including disease-associated proteins, can be
presented on the cell surface as peptide–human leukocyte antigen (pHLA) complexes. T …

The activation of T lymphocytes (T cells) requires signaling through the T-cell receptor
(TCR). The role of the coreceptor molecules, CD4 and CD8, is not clear, although they are …

The forces that govern clonal selection during the genesis and maintenance of specific T cell
responses are complex, but amenable to decryption by interrogation of constituent …

Cell-based antitumor immunity is driven by CD8+ cytotoxic T cells bearing TCR that
recognize specific tumor-associated peptides bound to class I MHC molecules. Of several …

Immune responses arise from a wide variety of cells expressing unique combinations of
multiple cell-surface proteins. Detailed characterization is hampered, however, by limitations …

BACKGROUND & AIMS: The immunoinhibitory receptor programmed death 1 (PD-1) is up-
regulated on dysfunctional virus-specific CD8 T cells during chronic viral infections, and …