Dissecting adipose tissue lipolysis: molecular regulation and implications for metabolic disease
Lipolysis is the process by which triglycerides (TGs) are hydrolyzed to free fatty acids (FFAs)
and glycerol. In adipocytes, this is achieved by sequential action of adipose TG lipase …
and glycerol. In adipocytes, this is achieved by sequential action of adipose TG lipase …
[HTML][HTML] Lipolysis–a highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores
A Lass, R Zimmermann, M Oberer, R Zechner - Progress in lipid research, 2011 - Elsevier
Lipolysis is the biochemical pathway responsible for the catabolism of triacylglycerol (TAG)
stored in cellular lipid droplets. The hydrolytic cleavage of TAG generates non-esterified fatty …
stored in cellular lipid droplets. The hydrolytic cleavage of TAG generates non-esterified fatty …
Mammalian triacylglycerol metabolism: synthesis, lipolysis, and signaling
RA Coleman, DG Mashek - Chemical reviews, 2011 - ACS Publications
Triacylglycerol (TAG) is the primary unit of energy storage in eukaryotic cells. TAG comprises
more than 90% of the content of white adipocytes, and TAG synthesis is essential in …
more than 90% of the content of white adipocytes, and TAG synthesis is essential in …
The role of lipid sensing nuclear receptors (PPARs and LXR) and metabolic lipases in obesity, diabetes and NAFLD
ED Dixon, AD Nardo, T Claudel, M Trauner - Genes, 2021 - mdpi.com
Obesity and type 2 diabetes mellitus (T2DM) are metabolic disorders characterized by
metabolic inflexibility with multiple pathological organ manifestations, including non …
metabolic inflexibility with multiple pathological organ manifestations, including non …
Alcohol, White Adipose Tissue, and Brown Adipose Tissue: Mechanistic Links to Lipogenesis and Lipolysis
According to data from the World Health Organization, there were about 3 million deaths
caused by alcohol consumption worldwide in 2016, of which about 50% were related to liver …
caused by alcohol consumption worldwide in 2016, of which about 50% were related to liver …
Activation of peroxisome proliferator-activated receptor-γ by rosiglitazone improves lipid homeostasis at the adipose tissue-liver axis in ethanol-fed mice
X Sun, Y Tang, X Tan, Q Li, W Zhong… - American Journal …, 2012 - journals.physiology.org
The development of alcohol-induced fatty liver is associated with a reduction of white
adipose tissue (WAT). Peroxisome proliferator-activated receptor (PPAR)-γ prominently …
adipose tissue (WAT). Peroxisome proliferator-activated receptor (PPAR)-γ prominently …
Modulation of myocellular fat stores: lipid droplet dynamics in health and disease
RCR Meex, P Schrauwen… - American Journal of …, 2009 - journals.physiology.org
Storage of fatty acids as triacylglycerol (TAG) occurs in almost all mammalian tissues.
Whereas adipose tissue is by far the largest storage site of fatty acids as TAG, subcellular …
Whereas adipose tissue is by far the largest storage site of fatty acids as TAG, subcellular …
Adipose triglyceride lipase affects triacylglycerol metabolism at brain barriers
K Etschmaier, T Becker, TO Eichmann… - Journal of …, 2011 - Wiley Online Library
J. Neurochem.(2011) 119, 1016–1028. Abstract Currently, little is known about the role of
intracellular triacylglycerol (TAG) lipases in the brain. Adipose triglyceride lipase (ATGL) is …
intracellular triacylglycerol (TAG) lipases in the brain. Adipose triglyceride lipase (ATGL) is …
Adipose triglyceride lipase expression in human adipose tissue and muscle. Role in insulin resistance and response to training and pioglitazone
A Yao-Borengasser, V Varma, RH Coker… - Metabolism, 2011 - Elsevier
Adipose triglyceride lipase (ATGL) catalyzes the first step in adipocyte and muscle
triglyceride hydrolysis, and comparative gene identification–58 (CGI-58) is an essential …
triglyceride hydrolysis, and comparative gene identification–58 (CGI-58) is an essential …
C1q/TNF-related protein 2 (CTRP2) deletion promotes adipose tissue lipolysis and hepatic triglyceride secretion
The highly conserved C1q/TNF-related protein (CTRP) family of secreted hormones has
emerged as important regulators of insulin action and of sugar and fat metabolisms. Among …
emerged as important regulators of insulin action and of sugar and fat metabolisms. Among …