Designing improved active peptides for therapeutic approaches against infectious diseases

B Gomes, MT Augusto, MR Felício, A Hollmann… - Biotechnology …, 2018 - Elsevier
Infectious diseases are one of the main causes of human morbidity and mortality. In the last
few decades, pathogenic microorganisms' resistance to conventional drugs has been …

Computational tools for exploring sequence databases as a resource for antimicrobial peptides

WF Porto, AS Pires, OL Franco - Biotechnology advances, 2017 - Elsevier
Data mining has been recognized by many researchers as a hot topic in different areas. In
the post-genomic era, the growing number of sequences deposited in databases has been …

Physicochemical-guided design of cathelicidin-derived peptides generates membrane active variants with therapeutic potential

NGJ Oliveira, MH Cardoso, N Velikova, M Giesbers… - Scientific Reports, 2020 - nature.com
The spread of multi-drug resistance and the slow pace at which antibiotics come onto the
market are undermining our ability to treat human infections, leading to high mortality rates …

Marine antimicrobial peptides: an emerging nightmare to the life-threatening pathogens

AM Thomas, SP Antony - Probiotics and Antimicrobial Proteins, 2024 - Springer
The emergence of multidrug-resistant pathogens due to improper usage of conventional
antibiotics has created a global health crisis. Alternatives to antibiotics being an urgent …

Bioactivity of synthetic peptides from Ecuadorian frog skin secretions against Leishmania mexicana, Plasmodium falciparum, and Trypanosoma cruzi

C Proaño-Bolaños, G Morán-Marcillo… - Microbiology …, 2024 - journals.asm.org
Chagas disease, leishmaniasis, and malaria are major parasitic diseases disproportionately
affecting the underprivileged population in developing nations. Finding new, alternative anti …

Antimicrobial peptides: effect on bacterial cells

MM Domingues, MR Felício, S Gonçalves - Atomic Force Microscopy …, 2019 - Springer
Antimicrobial peptides (AMPs) are one of the most promising alternatives to conventional
antibiotics. Atomic force microscopy (AFM), as imaging and force spectroscopy tool, has …