Annexin A2 (AnxA2) is a multifunctional calcium2+ (Ca2+) and phospholipid-binding protein
that is expressed in a wide spectrum of cells, including those participating in the …

Annexins are cytosolic proteins with conserved three-dimensional structures that bind acidic
phospholipids in cellular membranes at elevated Ca2+ levels. Through this they act as Ca2+ …

Muscle loss due to fibrotic or adipogenic replacement of myofibers is common in muscle
diseases and muscle-resident fibro/adipogenic precursors (FAPs) are implicated in this …

As a cell surface tissue plasminogen activator (tPA)-plasminogen receptor, the annexin A2
(A2) complex facilitates plasmin generation on the endothelial cell surface, and is an …

Membrane repair is essential to cell survival. In skeletal muscle, injury often associates with
plasma membrane disruption. Additionally, muscular dystrophy is linked to mutations in …

Plasma membrane forms the barrier between the cytoplasm and the environment. Cells
constantly and selectively transport molecules across their plasma membrane without …

Exercise generates a site-specific increase in Reactive Oxygen Species (ROS) within
muscle that promotes changes in gene transcription and mitochondrial biogenesis, required …

Muscle cell plasma membrane is frequently damaged by mechanical activity, and its repair
requires the membrane protein dysferlin. We previously identified that, similar to dysferlin …

Plasma membrane injury can cause lethal influx of calcium, but cells survive by mounting a
polarized repair response targeted to the wound site. Mitochondrial signaling within seconds …

Routine manipulation of the mouse genome has become a landmark in biomedical
research. Traits that are only associated with advanced developmental stages can now be …