[HTML][HTML] Mechanisms of long COVID and the path toward therapeutics

MJ Peluso, SG Deeks - Cell, 2024 - cell.com
Long COVID, a type of post-acute sequelae of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2)(PASC) defined by medically unexplained symptoms following …

Tissue-based T cell activation and viral RNA persist for up to 2 years after SARS-CoV-2 infection

MJ Peluso, D Ryder, RR Flavell, Y Wang… - Science translational …, 2024 - science.org
The mechanisms of postacute medical conditions and unexplained symptoms after SARS-
CoV-2 infection [Long Covid (LC)] are incompletely understood. There is growing evidence …

Total-body positron emission tomography: adding new perspectives to cardiovascular research

SR Cherry, J Diekmann, FM Bengel - Cardiovascular Imaging, 2023 - jacc.org
The recent advent of positron emission tomography (PET) scanners that can image the
entire human body opens up intriguing possibilities for cardiovascular research and future …

[HTML][HTML] Multimodal molecular imaging reveals tissue-based T cell activation and viral RNA persistence for up to 2 years following COVID-19

MJ Peluso, D Ryder, R Flavell, Y Wang, J Levi… - Medrxiv, 2023 - ncbi.nlm.nih.gov
The etiologic mechanisms of post-acute medical morbidities and unexplained symptoms
(Long COVID) following SARS-CoV-2 infection are incompletely understood. There is …

[18F]F-AraG imaging reveals association between neuroinflammation and brown- and bone marrow adipose tissue

J Levi, C Guglielmetti, TJ Henrich, JC Yoon… - Communications …, 2024 - nature.com
Brown and brown-like adipose tissues have attracted significant attention for their role in
metabolism and therapeutic potential in diabetes and obesity. Despite compelling evidence …

Quantitation of dynamic total-body PET imaging: recent developments and future perspectives

F Gu, Q Wu - European Journal of Nuclear Medicine and Molecular …, 2023 - Springer
Background Positron emission tomography (PET) scanning is an important diagnostic
imaging technique used in disease diagnosis, therapy planning, treatment monitoring, and …

[HTML][HTML] Total-Body PET/CT: Pros and Cons

RJ Hicks, RE Ware, J Callahan - Seminars in Nuclear Medicine, 2024 - Elsevier
PET/CT devices with an axial field-of-view (FOV) of 1 m allow simultaneous imaging from the
head to the upper thighs, the typical axial extent of many “whole-body” oncological studies …

The role of total-body PET in drug development and evaluation: status and outlook

X Meng, X Kong, L Xia, R Wu, H Zhu… - Journal of Nuclear …, 2024 - Soc Nuclear Med
Total-body PET, an emerging technique, enables high-quality simultaneous total-body
dynamic PET acquisition and accurate kinetic analysis. It has the potential to facilitate the …

Vascular pathogenesis in acute and long covid: Current insights and therapeutic outlook

A Kruger, D Joffe, G Lloyd-Jones… - … in Thrombosis and …, 2024 - thieme-connect.com
Long coronavirus disease 2019 (COVID-19)—a postacute consequence of severe acute
respiratory syndrome coronavirus 2 infection—manifests with a broad spectrum of relapsing …

Total Body PET/CT: A Role in Drug Development?

X Meng, X Kong, R Wu, Z Yang - Seminars in Nuclear Medicine, 2024 - Elsevier
Nowadays, total body PET has already entered the medical centers and enabled various
clinical applications due to its superior imaging capabilities, especially the high sensitivity …