Conserved signaling pathways that activate the mitogen-activated protein kinases (MAPKs)
are involved in relaying extracellular stimulations to intracellular responses. The MAPKs …

An appropriate response and adaptation to hyperosmolarity, ie., an external osmolarity that
is higher than the physiological range, can be a matter of life or death for all cells. It is …

Signaling pathways that activate different mitogen-activated protein kinases (MAPKs) elicit
many of the responses that are evoked in cells by changes in certain environmental …

RNA-binding proteins (RBPs) are essential for the development and function of the immune
system. They interact dynamically with RNA to control its biogenesis and turnover by …

Post-transcriptional processes have a central role in the regulation of eukaryotic gene
expression. Although it has been known for a long time that these processes are functionally …

Inherently unstable mammalian mRNAs contain AU-rich elements (AREs) within their 3′
untranslated regions. Although found 15 years ago, the mechanism by which AREs dictate …

We measured half-lives of 21,248 mRNA 3′ isoforms in yeast by rapidly depleting RNA
polymerase II from the nucleus and performing direct RNA sequencing throughout the decay …

Eukaryotic cells possess an exquisitely interwoven and fine-tuned series of signal
transduction mechanisms with which to sense and respond to the ubiquitous fermentable …

Unicellular organisms such as yeast have evolved to survive constant fluctuations in their
external surroundings by rapidly adapting their internal systems to meet the challenges of …

Iron (Fe) is an essential micronutrient for virtually all organisms and serves as a cofactor for
a wide variety of vital cellular processes. Although Fe deficiency is the primary nutritional …