The fundamental unit of pain is the cell
DB Reichling, PG Green, JD Levine - PAIN®, 2013 - Elsevier
The molecular/genetic era has seen the discovery of a staggering number of molecules
implicated in pain mechanisms [18],[35],[61],[69],[96],[133],[150],[202],[224]. This has …
implicated in pain mechanisms [18],[35],[61],[69],[96],[133],[150],[202],[224]. This has …
Gene therapy for diabetic peripheral neuropathy: A randomized, placebo‐controlled phase III study of VM202, a plasmid DNA encoding human hepatocyte growth …
JA Kessler, A Shaibani, CN Sang… - Clinical and …, 2021 - Wiley Online Library
VM202 is a plasmid DNA encoding two isoforms of hepatocyte growth factor (HGF). A
previous phase II study in subjects with painful diabetic peripheral neuropathy (DPN) …
previous phase II study in subjects with painful diabetic peripheral neuropathy (DPN) …
Poly (lactic-co-glycolic acid) nanomaterial-based treatment options for pain management: A review
TL Phạm, DW Kim - Nanomedicine, 2020 - Taylor & Francis
Neuropathic pain is one of the most intense types of chronic pain; it constitutes a pervasive
complaint throughout the public health system. With few effective treatments, it remains a …
complaint throughout the public health system. With few effective treatments, it remains a …
Recent Advances in Management of Neuropathic, Nociceptive, and Chronic Pain: A Narrative Review with Focus on Nanomedicine, Gene Therapy, Stem Cell …
Abstract Purpose of Review This manuscript summarizes novel clinical and interventional
approaches in the management of chronic, nociceptive, and neuropathic pain. Recent …
approaches in the management of chronic, nociceptive, and neuropathic pain. Recent …
Ex vivo nonviral gene delivery of μ-opioid receptor to attenuate cancer-induced pain
S Yamano, CT Viet, D Dang, J Dai, S Hanatani… - Pain, 2017 - journals.lww.com
Virus-mediated gene delivery shows promise for the treatment of chronic pain. However,
viral vectors have cytotoxicity. To avoid toxicities and limitations of virus-mediated gene …
viral vectors have cytotoxicity. To avoid toxicities and limitations of virus-mediated gene …
[HTML][HTML] Intrathecal administration of mesenchymal stem cells reduces the reactive oxygen species and pain behavior in neuropathic rats
EJ Zhang, CH Song, YK Ko… - The Korean Journal of …, 2014 - synapse.koreamed.org
Background Neuropathic pain induced by spinal or peripheral nerve injury is very resistant
to common pain killers, nerve block, and other pain management approaches. Recently …
to common pain killers, nerve block, and other pain management approaches. Recently …
Suppression of pain by gene editing
JP Maianti, DR Liu - US Patent 11,898,179, 2024 - Google Patents
2022-03-23 Assigned to PRESIDENT AND FELLOWS OF HARVARD COLLEGE
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …
Comparative effectiveness of antinociceptive gene therapies in animal models of diabetic neuropathic pain
Y Wang, MO Nowicki, X Wang, WD Arnold… - Gene therapy, 2013 - nature.com
Peripheral neuropathic pain is one of the most common and debilitating complications of
diabetes. Several genes have been shown to be effective in reducing neuropathic pain in …
diabetes. Several genes have been shown to be effective in reducing neuropathic pain in …
[HTML][HTML] Efficacy of herpes simplex virus vector encoding the human preproenkephalin gene for treatment of facial pain in mice
F Ma, C Wang, WE Yoder, KN Westlund… - Journal of oral & …, 2016 - ncbi.nlm.nih.gov
Aims To determine whether herpes simplex virus–based vectors can efficiently transduce
mouse trigeminal ganglion (TG) neurons and attenuate preexisting nerve injury–induced …
mouse trigeminal ganglion (TG) neurons and attenuate preexisting nerve injury–induced …
Use of naturally occurring peptides for neuropathic spinal cord injury pain
A Hama, J Sagen - Current Protein and Peptide Science, 2013 - ingentaconnect.com
Spinal cord injury (SCI) is accompanied by intractable pain as well as loss of motor and
visceral control. As part of an overall strategy in patient rehabilitation and improvement in …
visceral control. As part of an overall strategy in patient rehabilitation and improvement in …