Pruritus in cholestatic liver diseases can be a major burden and dramatically impair the
quality of life of those affected. Here, we provide an update on the latest insights into the …

Sumatriptan is the first available medication from triptans family that was approved by the US
Food and Drug Administration for migraine attacks and cluster headaches in 1991. Most of …

Itching is an unpleasant sensation that provokes the desire to scratch. In general, itching is
caused by dermatologic diseases, but it can also be caused by systemic diseases. Since …

Cholestasis, a condition characterized by an abnormal decrease in bile flow, is
accompanied by various symptoms such as pruritus. Although cholestatic pruritus is a …

Primary biliary cholangitis (PBC) is the most common chronic cholestatic liver disease in
adults in the United States and is characterized by inflammation targeting cholangiocytes of …

Chloroquine (CQ) is an antimalarial drug that elicits severe pruritus in black Africans with
malaria fever. This acute itching (2–7 days duration) exhibits age dependency and a racial …

Introduction: In many types of itch, the interaction between immune system cells,
keratinocytes, and sensory nerves involved in the transmission of itch is quite complex …

Background Pruritus, or itching, is a distressing symptom associated with various
dermatological and systemic diseases. L-carnitine (βeta hydroxy-γ-tri methyl amino-butyric …

Pruritus is one of the most distressing symptoms in cholestatic patients. Plasma autotaxin
(ATX) activity correlates with the severity of pruritus in cholestatic patients, but the …

Oxytocin (OT), a hormone synthesized within the paraventricular nucleus and supraoptic
nucleus of the hypothalamus, when given intracerebroventricularly, induces strong …