[HTML][HTML] A review of the basics of mitochondrial bioenergetics, metabolism, and related signaling pathways in cancer cells: Therapeutic targeting of tumor mitochondria …
The present review is a sequel to the previous review on cancer metabolism published in
this journal. This review focuses on the selective antiproliferative and cytotoxic effects of …
this journal. This review focuses on the selective antiproliferative and cytotoxic effects of …
Stable isotope tracing to assess tumor metabolism in vivo
Cancer cells undergo diverse metabolic adaptations to meet the energetic demands
imposed by dysregulated growth and proliferation. Assessing metabolism in intact tumors …
imposed by dysregulated growth and proliferation. Assessing metabolism in intact tumors …
The glutamate/cystine xCT antiporter antagonizes glutamine metabolism and reduces nutrient flexibility
CS Shin, P Mishra, JD Watrous, V Carelli… - Nature …, 2017 - nature.com
As noted by Warburg, many cancer cells depend on the consumption of glucose. We
performed a genetic screen to identify factors responsible for glucose addiction and …
performed a genetic screen to identify factors responsible for glucose addiction and …
Deletion of amino acid transporter ASCT2 (SLC1A5) reveals an essential role for transporters SNAT1 (SLC38A1) and SNAT2 (SLC38A2) to sustain glutaminolysis in …
Many cancer cells depend on glutamine as they use the glutaminolysis pathway to generate
building blocks and energy for anabolic purposes. As a result, glutamine transporters are …
building blocks and energy for anabolic purposes. As a result, glutamine transporters are …
Macrophages are metabolically heterogeneous within the tumor microenvironment
X Geeraerts, J Fernandez-Garcia, FJ Hartmann… - Cell reports, 2021 - cell.com
Macrophages are often prominently present in the tumor microenvironment, where distinct
macrophage populations can differentially affect tumor progression. Although metabolism …
macrophage populations can differentially affect tumor progression. Although metabolism …
[HTML][HTML] Loss of CD4+ T cell-intrinsic arginase 1 accelerates Th1 response kinetics and reduces lung pathology during influenza infection
Summary Arginase 1 (Arg1), the enzyme catalyzing the conversion of arginine to ornithine,
is a hallmark of IL-10-producing immunoregulatory M2 macrophages. However, its …
is a hallmark of IL-10-producing immunoregulatory M2 macrophages. However, its …
Cytosolic aldose metabolism contributes to progression from cirrhosis to hepatocarcinogenesis
Oxidative stress modulates carcinogenesis in the liver; however, direct evidence for
metabolic control of oxidative stress during pathogenesis, particularly, of progression from …
metabolic control of oxidative stress during pathogenesis, particularly, of progression from …
Gastric cancer: metabolic and metabolomics perspectives
S Xiao, L Zhou - International Journal of Oncology, 2017 - spandidos-publications.com
Gastric cancer is one of the most malignant tumors worldwide and remains a major health
threat in Asia-Pacific regions, while its pathological mechanism is generally unknown …
threat in Asia-Pacific regions, while its pathological mechanism is generally unknown …
MYCN amplification and ATRX mutations are incompatible in neuroblastoma
Aggressive cancers often have activating mutations in growth-controlling oncogenes and
inactivating mutations in tumor-suppressor genes. In neuroblastoma, amplification of the …
inactivating mutations in tumor-suppressor genes. In neuroblastoma, amplification of the …
Redox control of glutamine utilization in cancer
L Alberghina, D Gaglio - Cell death & disease, 2014 - nature.com
Glutamine utilization promotes enhanced growth of cancer cells. We propose a new concept
map of cancer metabolism in which mitochondrial NADH and NADPH, in the presence of a …
map of cancer metabolism in which mitochondrial NADH and NADPH, in the presence of a …