Coronary heart disease (CHD) is a common heart disease and the leading cause of
cardiovascular death. Apoptosis and autophagy are two forms of programmed cell deaths …

Reactive oxygen and nitrogen species change cellular responses through diverse
mechanisms that are now being defined. At low levels, they are signalling molecules, and at …

The progressive loss of cardiomyocytes caused by cell death leads to cardiac dysfunction
and heart failure (HF). Rapamycin has been shown to be cardioprotective in pressure …

Reactive oxygen species (ROS) are small and highly reactive molecules that can oxidize
proteins, lipids and DNA. When tightly controlled, ROS serve as signaling molecules by …

Ischemic preconditioning (IPC) affords tissue protection in organs including kidneys;
however, the underlying mechanism remains unclear. Here we demonstrate an important …

Type I programmed cell death (PCD) or apoptosis is critical for cellular self-destruction for a
variety of processes such as development or the prevention of oncogenic transformation …

Cardiovascular disease is the leading cause of death worldwide. As such, there is great
interest in identifying novel mechanisms that govern the cardiovascular response to disease …

The field of mitochondrial ion channels has recently seen substantial progress, including the
molecular identification of some of the channels. An integrative approach using genetics …

Under normal physiological conditions, reactive oxygen species (ROS) serve as 'redox
messengers' in the regulation of intracellular signalling, whereas excess ROS may induce …

Autophagy is a catabolic recycling pathway triggered by various intra-or extracellular stimuli
that is conserved from yeast to mammals. During autophagy, diverse cytosolic constituents …