Environmental factors in declining human fertility
NE Skakkebæk, R Lindahl-Jacobsen… - Nature Reviews …, 2022 - nature.com
A severe decline in child births has occurred over the past half century, which will lead to
considerable population declines, particularly in industrialized regions. A crucial question is …
considerable population declines, particularly in industrialized regions. A crucial question is …
Sexual dimorphism in innate immunity: the role of sex hormones and epigenetics
Sexual dimorphism refers to differences between biological sexes that extend beyond
sexual characteristics. In humans, sexual dimorphism in the immune response has been …
sexual characteristics. In humans, sexual dimorphism in the immune response has been …
Socioeconomic disadvantage and the pace of biological aging in children
METHODS: Saliva DNA methylation and socioeconomic circumstances were measured in
N= 600 children and adolescents aged 8 to 18 years (48% female) participating in the Texas …
N= 600 children and adolescents aged 8 to 18 years (48% female) participating in the Texas …
The congenital and acquired mechanisms implicated in the etiology of central precocious puberty
The etiology of central precocious puberty (CPP) is multiple and heterogeneous, including
congenital and acquired causes that can be associated with structural or functional brain …
congenital and acquired causes that can be associated with structural or functional brain …
Endocrine-disrupting chemicals and their effects on puberty
D Lopez-Rodriguez, D Franssen, S Heger… - Best practice & research …, 2021 - Elsevier
Sexual maturation in humans is characterized by a unique individual variability. Pubertal
onset is a highly heritable polygenic trait but it is also affected by environmental factors such …
onset is a highly heritable polygenic trait but it is also affected by environmental factors such …
Molecular basis of normal and pathological puberty: from basic mechanisms to clinical implications
Puberty is a major maturational event; its mechanisms and timing are driven by genetic
determinants, but also controlled by endogenous and environmental cues. Substantial …
determinants, but also controlled by endogenous and environmental cues. Substantial …
Autosomal sex-associated co-methylated regions predict biological sex from DNA methylation
E Gatev, AM Inkster, GL Negri, C Konwar… - Nucleic Acids …, 2021 - academic.oup.com
Sex is a modulator of health that has been historically overlooked in biomedical research.
Recognizing this knowledge gap, funding agencies now mandate the inclusion of sex as a …
Recognizing this knowledge gap, funding agencies now mandate the inclusion of sex as a …
Disentangling puberty: novel neuroendocrine pathways and mechanisms for the control of mammalian puberty
MS Avendaño, MJ Vazquez… - Human Reproduction …, 2017 - academic.oup.com
BACKGROUND Puberty is a complex developmental event, controlled by sophisticated
regulatory networks that integrate peripheral and internal cues and impinge at the brain …
regulatory networks that integrate peripheral and internal cues and impinge at the brain …
Association between the timing of childhood adversity and epigenetic patterns across childhood and adolescence: findings from the Avon Longitudinal Study of …
Background Childhood adversity is a potent determinant of health across development and
is associated with altered DNA methylation signatures, which might be more common in …
is associated with altered DNA methylation signatures, which might be more common in …
Genetic, epigenetic and enviromental influencing factors on the regulation of precocious and delayed puberty
MF Faienza, F Urbano, LA Moscogiuri… - Frontiers in …, 2022 - frontiersin.org
The pubertal development onset is controlled by a network of genes that regulate the
gonadotropin releasing hormone (GnRH) pulsatile release and the subsequent increase of …
gonadotropin releasing hormone (GnRH) pulsatile release and the subsequent increase of …