A severe decline in child births has occurred over the past half century, which will lead to
considerable population declines, particularly in industrialized regions. A crucial question is …

Sexual dimorphism refers to differences between biological sexes that extend beyond
sexual characteristics. In humans, sexual dimorphism in the immune response has been …

METHODS: Saliva DNA methylation and socioeconomic circumstances were measured in
N= 600 children and adolescents aged 8 to 18 years (48% female) participating in the Texas …

The etiology of central precocious puberty (CPP) is multiple and heterogeneous, including
congenital and acquired causes that can be associated with structural or functional brain …

Sexual maturation in humans is characterized by a unique individual variability. Pubertal
onset is a highly heritable polygenic trait but it is also affected by environmental factors such …

Puberty is a major maturational event; its mechanisms and timing are driven by genetic
determinants, but also controlled by endogenous and environmental cues. Substantial …

Sex is a modulator of health that has been historically overlooked in biomedical research.
Recognizing this knowledge gap, funding agencies now mandate the inclusion of sex as a …

BACKGROUND Puberty is a complex developmental event, controlled by sophisticated
regulatory networks that integrate peripheral and internal cues and impinge at the brain …

Background Childhood adversity is a potent determinant of health across development and
is associated with altered DNA methylation signatures, which might be more common in …

The pubertal development onset is controlled by a network of genes that regulate the
gonadotropin releasing hormone (GnRH) pulsatile release and the subsequent increase of …