Environmental factors in declining human fertility

NE Skakkebæk, R Lindahl-Jacobsen… - Nature Reviews …, 2022 - nature.com
A severe decline in child births has occurred over the past half century, which will lead to
considerable population declines, particularly in industrialized regions. A crucial question is …

Sexual dimorphism in innate immunity: the role of sex hormones and epigenetics

R Shepherd, AS Cheung, K Pang, R Saffery… - Frontiers in …, 2021 - frontiersin.org
Sexual dimorphism refers to differences between biological sexes that extend beyond
sexual characteristics. In humans, sexual dimorphism in the immune response has been …

Socioeconomic disadvantage and the pace of biological aging in children

L Raffington, DW Belsky, M Kothari, M Malanchini… - …, 2021 - publications.aap.org
METHODS: Saliva DNA methylation and socioeconomic circumstances were measured in
N= 600 children and adolescents aged 8 to 18 years (48% female) participating in the Texas …

The congenital and acquired mechanisms implicated in the etiology of central precocious puberty

VN Brito, APM Canton, CE Seraphim… - Endocrine …, 2023 - academic.oup.com
The etiology of central precocious puberty (CPP) is multiple and heterogeneous, including
congenital and acquired causes that can be associated with structural or functional brain …

Endocrine-disrupting chemicals and their effects on puberty

D Lopez-Rodriguez, D Franssen, S Heger… - Best practice & research …, 2021 - Elsevier
Sexual maturation in humans is characterized by a unique individual variability. Pubertal
onset is a highly heritable polygenic trait but it is also affected by environmental factors such …

Molecular basis of normal and pathological puberty: from basic mechanisms to clinical implications

J Argente, L Dunkel, UB Kaiser… - The Lancet Diabetes & …, 2023 - thelancet.com
Puberty is a major maturational event; its mechanisms and timing are driven by genetic
determinants, but also controlled by endogenous and environmental cues. Substantial …

Autosomal sex-associated co-methylated regions predict biological sex from DNA methylation

E Gatev, AM Inkster, GL Negri, C Konwar… - Nucleic Acids …, 2021 - academic.oup.com
Sex is a modulator of health that has been historically overlooked in biomedical research.
Recognizing this knowledge gap, funding agencies now mandate the inclusion of sex as a …

Disentangling puberty: novel neuroendocrine pathways and mechanisms for the control of mammalian puberty

MS Avendaño, MJ Vazquez… - Human Reproduction …, 2017 - academic.oup.com
BACKGROUND Puberty is a complex developmental event, controlled by sophisticated
regulatory networks that integrate peripheral and internal cues and impinge at the brain …

Association between the timing of childhood adversity and epigenetic patterns across childhood and adolescence: findings from the Avon Longitudinal Study of …

AA Lussier, Y Zhu, BJ Smith, J Cerutti… - The Lancet Child & …, 2023 - thelancet.com
Background Childhood adversity is a potent determinant of health across development and
is associated with altered DNA methylation signatures, which might be more common in …

Genetic, epigenetic and enviromental influencing factors on the regulation of precocious and delayed puberty

MF Faienza, F Urbano, LA Moscogiuri… - Frontiers in …, 2022 - frontiersin.org
The pubertal development onset is controlled by a network of genes that regulate the
gonadotropin releasing hormone (GnRH) pulsatile release and the subsequent increase of …