[HTML][HTML] Update on the epidemiology, pathogenesis, and biomarkers of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy

Y Yamamoto, YC Liao, YC Lee, M Ihara… - Journal of Clinical …, 2023 - ncbi.nlm.nih.gov
Cerebral autosomal dominant arteriopathy with subcortical infarcts and
leukoencephalopathy (CADASIL) is the most common monogenic disorder of the cerebral …

Clinical and genetic aspects of CADASIL

T Mizuno, I Mizuta, A Watanabe-Hosomi… - Frontiers in aging …, 2020 - frontiersin.org
Cerebral autosomal dominant arteriopathy with subcortical infarcts and
leukoencephalopathy (CADASIL), a hereditary cerebral small vessel disease caused by …

Genetic profiles of 103,106 individuals in the Taiwan Biobank provide insights into the health and history of Han Chinese

CY Wei, JH Yang, EC Yeh, MF Tsai, HJ Kao… - NPJ genomic …, 2021 - nature.com
Personalized medical care focuses on prediction of disease risk and response to
medications. To build the risk models, access to both large-scale genomic resources and …

Three-tiered EGFr domain risk stratification for individualized NOTCH3-small vessel disease prediction

RJ Hack, G Gravesteijn, MN Cerfontaine, MA Santcroos… - Brain, 2023 - academic.oup.com
Cysteine-altering missense variants (NOTCH3 cys) in one of the 34 epidermal growth-factor-
like repeat (EGFr) domains of the NOTCH3 protein are the cause of NOTCH3-associated …

Phenotypic variability in 446 CADASIL patients: Impact of NOTCH3 gene mutation location in addition to the effects of age, sex and vascular risk factors

C Dupé, S Guey, L Biard, S Dieng… - Journal of Cerebral …, 2023 - journals.sagepub.com
The recent discovery that the prevalence of cysteine mutations in the NOTCH3 gene
responsible for CADASIL was more than 100 times higher in the general population than …

Genetic spectrum of NOTCH3 and clinical phenotype of CADASIL patients in different populations

W Ni, Y Zhang, L Zhang, JJ Xie, HF Li… - CNS neuroscience & …, 2022 - Wiley Online Library
Introduction Cerebral autosomal‐dominant arteriopathy with subcortical infarcts and
leukoencephalopathy (CADASIL) is a relatively common cerebral small vessel disease …

[HTML][HTML] Intracerebral hemorrhage in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy

YC Liao, YC Hu, CP Chung, YF Wang, YC Guo… - Stroke, 2021 - journals.lww.com
Background and Purpose: Cerebral autosomal dominant arteriopathy with subcortical
infarcts and leukoencephalopathy (CADASIL) is a monogenic cerebral small vessel disease …

NOTCH3 Variants and Genotype-Phenotype Features in Chinese CADASIL Patients

Y Hu, Q Sun, Y Zhou, F Yi, H Tang, L Yao, Y Tian… - Frontiers in …, 2021 - frontiersin.org
Cerebral autosomal dominant arteriopathy with subcortical infarcts and
leukoencephalopathy (CADASIL) is a cerebral small vessel disease caused by mutations in …

Pro‐Hemorrhagic Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy Associated with NOTCH3 p.R75P Mutation with …

H Ishiyama, H Kim, S Saito, S Takeda… - Annals of …, 2024 - Wiley Online Library
Objectives Intracerebral hemorrhage (ICH) and cerebral microbleeds (CMB) in cerebral
autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy are …

Etiology and risk factors of intracranial hemorrhage and ischemic stroke in young adults

CY Chen, PT Lin, YH Wang, RW Syu… - Journal of the …, 2021 - journals.lww.com
Background: Young stroke incidence has increased worldwide with lifestyle changes.
Etiology and risk factors for both ischemic and hemorrhagic stroke in young Asians remain …