Mammalian studies have shaped our understanding of the endocrine control of appetite and
body weight in vertebrates and provided the basic vertebrate model that involves central …

G protein–coupled receptors (GPCRs) are major regulators of intercellular interactions. They
initiate these actions by being activated by a wide variety of natural ligands. Historically …

Despite the well-known health benefits of physical activity, many people underexercise;
what drives the prioritization of exercise over alternative options is unclear. We developed a …

Endogenous cannabinoid signalling is widespread throughout the body, and considerable
evidence supports its modulatory role in many fundamental physiological processes. The …

Orexins comprise two neuropeptides produced by orexin neurons in the lateral
hypothalamus and are released by extensive projections of these neurons throughout the …

Ingested nutrients are proposed to control mammalian behavior by modulating the activity of
hypothalamic orexin/hypocretin neurons (HONs). Previous in vitro studies showed that …

Migraine and obesity are two public health problems of enormous scope that are
responsible for significant quality of life impairment and financial cost. Recent research …

The wake-active orexin system plays a central role in the dynamic regulation of glucose
homeostasis. Here we show orexin receptor type 1 and 2 are predominantly expressed in …

Specific neurons in the lateral hypothalamus produce the orexin neuropeptides (orexin-A
and orexin-B). The orexin-peptides are transported to areas of the brain regulating sleep …

Since its discovery in 1998, the orexin system has been of interest to the research
community as a potential therapeutic target for the treatment of sleep/wake disorders, stress …