Potential mechanisms of action of lithium in bipolar disorder: Current understanding

GS Malhi, M Tanious, P Das, CM Coulston, M Berk - CNS drugs, 2013 - Springer
Lithium has been used for over half a century for the treatment of bipolar disorder as the
archetypal mood stabilizer, and has a wealth of empirical evidence supporting its efficacy in …

Brain insulin resistance and deficiency as therapeutic targets in Alzheimer's disease

S M. de la Monte - Current Alzheimer Research, 2012 - benthamdirect.com
Alzheimer's disease [AD] is the most common cause of dementia in North America. Despite
30+ years of intense investigation, the field lacks consensus regarding the etiology and …

[HTML][HTML] Dual role of autophagy in diseases of the central nervous system

T Bar-Yosef, O Damri, G Agam - Frontiers in cellular neuroscience, 2019 - frontiersin.org
Autophagy is a vital lysosomal degradation and recycling pathway in the eukaryotic cell,
responsible for maintaining an intricate balance between cell survival and cell death …

Is lithium neuroprotective? An updated mechanistic illustrated review

F Ghanaatfar, A Ghanaatfar, P Isapour… - Fundamental & …, 2023 - Wiley Online Library
Neurodegeneration is a pathological process characterized by progressive neuronal
impairment, dysfunction, and loss due to mitochondrial dysfunction, oxidative stress …

A new look at an old drug: neuroprotective effects and therapeutic potentials of lithium salts

L Dell'Osso, C Del Grande, C Gesi… - Neuropsychiatric …, 2016 - Taylor & Francis
Increasing evidence highlights bipolar disorder as being associated with impaired
neurogenesis, cellular plasticity, and resiliency, as well as with cell atrophy or loss in specific …

A review: treatment of Alzheimer's disease discovered in repurposed agents

BS Appleby, D Nacopoulos, N Milano… - Dementia and geriatric …, 2013 - karger.com
Abstract Background/Aims: Many compounds that have already been approved for alternate
diagnoses have been studied in relation to Alzheimer's disease (AD). The purpose of this …

Discovering new treatments for Alzheimer's disease by repurposing approved medications

BS Appleby, JL Cummings - Current Topics in Medicinal …, 2013 - ingentaconnect.com
Alzheimer's disease (AD) is the most common cause of dementia and a major cause of
morbidity and mortality. The greatest risk factor for AD is age and as many countries are …

Midlife predictors of Alzheimer's disease

BB Bendlin, CM Carlsson, CE Gleason, SC Johnson… - Maturitas, 2010 - Elsevier
Factors contributing to increased risk for Alzheimer's disease (AD) include age, sex, genes,
and family history of AD. Several risk factors for AD are endogenous; however, accumulating …

Potential of therapeutic small molecules in apoptosis regulation in the treatment of neurodegenerative diseases: An updated review

HG Dailah - Molecules, 2022 - mdpi.com
Neurodegenerative disorders (NDs) include Parkinson's disease (PD), Alzheimer's disease
(AD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS) and the common …

Lithium: a versatile tool for understanding renal physiology

BK Kishore, CM Ecelbarger - American Journal of …, 2013 - journals.physiology.org
By virtue of its unique interactions with kidney cells, lithium became an important research
tool in renal physiology and pathophysiology. Investigators have uncovered the intricate …