Cell death is a fundamental biological phenomenon that is essential for the survival and
development of an organism. Emerging evidence also indicates that cell death contributes to …

Endoplasmic reticulum stress (ERS) is a protective response to restore protein homeostasis
by activating the unfolded protein response (UPR). However, UPR can trigger cell death …

Macrophage polarization to proinflammatory M1-like or anti-inflammatory M2-like cells is
critical to mount a host defense or repair tissue. The exact molecular mechanisms controlling …

Macrophages are mononuclear phagocytes which derive either from blood-borne
monocytes or reside as resident macrophages in peripheral (Kupffer cells of the liver …

Infection is a dynamic biological process underpinned by a complex interplay between the
pathogen and the host. Microbes from all domains of life, including bacteria, viruses, fungi …

The NLRP3 (NLR family pyrin domain containing 3) inflammasome is involved in diverse
inflammatory diseases, thus strict control of its activation is necessary to prevent excessive …

Background Spinal cord injury (SCI) is a devastating disease, which results in tissue loss
and neurologic dysfunction. NLRP3 inflammasome plays an important role in the …

The global coronavirus disease 2019 (COVID-19) pandemic has deranged the recent
history of humankind, afflicting more than 27 million individuals to date. While the majority of …

Resveratrol alleviates chronic “real-world” ambient particulate matter-induced lung
inflammation and fibrosis by inhibiting NLRP3 inflammasome activation in mice …

Cinnamaldehyde (CA) is an essential component of cinnamon (Cinnamomum cassia
Presland), which is often used as a flavoring condiment in beverages, pastries, perfumes …