[HTML][HTML] Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity

H Cao, L Duan, Y Zhang, J Cao, K Zhang - Signal transduction and …, 2021 - nature.com
Hydrogel is a type of versatile platform with various biomedical applications after rational
structure and functional design that leverages on material engineering to modulate its …

[HTML][HTML] 3D in vitro model (R) evolution: unveiling tumor–stroma interactions

J Rodrigues, MA Heinrich, LM Teixeira, J Prakash - Trends in cancer, 2021 - cell.com
The complex microenvironment in which malignant tumor cells grow is crucial for cancer
progression. The physical and biochemical characteristics of this niche are involved in …

Tumor microenvironment signaling and therapeutics in cancer progression

A Goenka, F Khan, B Verma, P Sinha… - Cancer …, 2023 - Wiley Online Library
Tumor development and metastasis are facilitated by the complex interactions between
cancer cells and their microenvironment, which comprises stromal cells and extracellular …

Cyclooxygenase‐2 in cancer: a review

N Hashemi Goradel, M Najafi, E Salehi… - Journal of cellular …, 2019 - Wiley Online Library
Abstract Cyclooxygenase‐2 (COX‐2) is frequently expressed in many types of cancers
exerting a pleiotropic and multifaceted role in genesis or promotion of carcinogenesis and …

Extracellular matrix (ECM) stiffness and degradation as cancer drivers

M Najafi, B Farhood… - Journal of cellular …, 2019 - Wiley Online Library
Alteration in the density and composition of extracellular matrix (ECM) occurs in tumors. The
alterations toward both stiffness and degradation are contributed to tumor growth and …

Advances in Spheroids and Organoids on a Chip

G Fang, YC Chen, H Lu, D Jin - Advanced Functional Materials, 2023 - Wiley Online Library
Multicellular spheroids and organoids are promising in vitro 3D models in personalized
medicine and drug screening. They replicate the structural and functional characteristics of …

Biomaterial-based platforms for tumour tissue engineering

R Curvello, V Kast, P Ordóñez-Morán, A Mata… - Nature Reviews …, 2023 - nature.com
Tissue engineering has produced innovative tools for cancer research. 3D cancer models
based on molecularly designed biomaterials aim to harness the dimensionality and …

Breast cancer models: Engineering the tumor microenvironment

G Bahcecioglu, G Basara, BW Ellis, X Ren, P Zorlutuna - Acta biomaterialia, 2020 - Elsevier
The mechanisms behind cancer initiation and progression are not clear. Therefore,
development of clinically relevant models to study cancer biology and drug response in …

Three‐dimensional multicellular biomaterial platforms for biomedical application

J Hao, C Qin, C Wu - Interdisciplinary Materials, 2023 - Wiley Online Library
Abstract The three‐dimensional (3D) multicellular platforms prepared by cells or
biomaterials have been widely applied in biomedical fields for the regeneration of complex …

Contribution of regulatory T cells to cancer: A review

M Najafi, B Farhood… - Journal of cellular …, 2019 - Wiley Online Library
Regulatory T cells (Tregs) represent a low number of T‐cell population under normal
conditions, and they play key roles for maintaining immune system in homeostasis. The …