[HTML][HTML] Saponins in cancer treatment: Current progress and future prospects

OO Elekofehinti, O Iwaloye, F Olawale, EO Ariyo - Pathophysiology, 2021 - mdpi.com
Saponins are steroidal or triterpenoid glycoside that is distinguished by the soap-forming
nature. Different saponins have been characterized and purified and are gaining attention in …

[HTML][HTML] Therapeutic effects on cancer of the active ingredients in rhizoma paridis

J Li, J Jia, W Zhu, J Chen, Q Zheng, D Li - Frontiers in Pharmacology, 2023 - frontiersin.org
Cancer is a major threat to human health, with high mortality and a low cure rate,
continuously challenging public health worldwide. Extensive clinical application of …

[HTML][HTML] Berberine protects against 6-OHDA-induced neurotoxicity in PC12 cells and zebrafish through hormetic mechanisms involving PI3K/AKT/Bcl-2 and Nrf2/HO-1 …

C Zhang, C Li, S Chen, Z Li, X Jia, K Wang, J Bao… - Redox biology, 2017 - Elsevier
Berberine (BBR) is a renowned natural compound that exhibits potent neuroprotective
activities. However, the cellular and molecular mechanisms are still unclear. Hormesis is an …

Liver ASK1 protects from non‐alcoholic fatty liver disease and fibrosis

TD Challa, S Wueest, FC Lucchini… - EMBO molecular …, 2019 - embopress.org
Non‐alcoholic fatty liver disease (NAFLD) is strongly associated with obesity and may
progress to non‐alcoholic steatohepatitis (NASH) and liver fibrosis. The deficit of …

[HTML][HTML] In vitro and in vivo anti-inflammatory effects of polyphyllin VII through downregulating MAPK and NF-κB pathways

C Zhang, C Li, X Jia, K Wang, Y Tu, R Wang, K Liu… - Molecules, 2019 - mdpi.com
Background: Polyphyllin VII (PP7), a steroidal saponin from Paris polyphylla, has been
found to exert strong anticancer activity. Little is known about the anti-inflammatory property …

[HTML][HTML] Endoplasmic reticulum stress eIF2α–ATF4 pathway-mediated cyclooxygenase-2 induction regulates cadmium-induced autophagy in kidney

B Luo, Y Lin, S Jiang, L Huang, H Yao, Q Zhuang… - Cell death & …, 2016 - nature.com
The heavy metal cadmium (Cd) is nephrotoxic. Recent studies show that autophagy plays
an essential role in Cd-induced kidney injury. However, the mechanisms of Cd-induced …

Polyphyllin VII induces autophagy‐dependent ferroptosis in human gastric cancer through targeting T‐lymphokine‐activated killer cell‐originated protein kinase

Y Xiang, F Wan, Y Ren, D Yang, K Xiang… - Phytotherapy …, 2023 - Wiley Online Library
T‐lymphokine‐activated killer cell‐originated protein kinase (TOPK) is a serine–threonine
kinase that is overexpressed in gastric cancer (GC) and promotes tumor progression …

Polyphyllin VII promotes apoptosis and Autophagic cell death via ROS‐inhibited AKT activity, and sensitizes Glioma cells to Temozolomide

D Pang, C Li, C Yang, Y Zou, B Feng… - Oxidative medicine …, 2019 - Wiley Online Library
The high recurrence frequency of gliomas but deficiency of effective treatment and prevalent
chemoresistance have elicited interests in exploring and developing new agents. Paris …

[HTML][HTML] Programmed cell death alterations mediated by synthetic indole chalcone resulted in cell cycle arrest, DNA damage, apoptosis and signaling pathway …

R Michalkova, M Kello, Z Kudlickova, M Gazdova… - Pharmaceutics, 2022 - mdpi.com
Although new chemotherapy significantly increased the survival of breast cancer (BC)
patients, the use of these drugs is often associated with serious toxicity. The discovery of …

[HTML][HTML] Polyphyllin I induces autophagy and cell cycle arrest via inhibiting PDK1/Akt/mTOR signal and downregulating cyclin B1 in human gastric carcinoma HGC-27 …

J He, S Yu, C Guo, L Tan, X Song, M Wang… - Biomedicine & …, 2019 - Elsevier
Paris polyphylla. is a traditional medicinal herb that has long been used to prevent cancer in
many Asian countries. Polyphyllin I (PPI), an important bioactive constituent of Paris …