Saponins are steroidal or triterpenoid glycoside that is distinguished by the soap-forming
nature. Different saponins have been characterized and purified and are gaining attention in …

Cancer is a major threat to human health, with high mortality and a low cure rate,
continuously challenging public health worldwide. Extensive clinical application of …

Berberine (BBR) is a renowned natural compound that exhibits potent neuroprotective
activities. However, the cellular and molecular mechanisms are still unclear. Hormesis is an …

Non‐alcoholic fatty liver disease (NAFLD) is strongly associated with obesity and may
progress to non‐alcoholic steatohepatitis (NASH) and liver fibrosis. The deficit of …

Background: Polyphyllin VII (PP7), a steroidal saponin from Paris polyphylla, has been
found to exert strong anticancer activity. Little is known about the anti-inflammatory property …

The heavy metal cadmium (Cd) is nephrotoxic. Recent studies show that autophagy plays
an essential role in Cd-induced kidney injury. However, the mechanisms of Cd-induced …

T‐lymphokine‐activated killer cell‐originated protein kinase (TOPK) is a serine–threonine
kinase that is overexpressed in gastric cancer (GC) and promotes tumor progression …

The high recurrence frequency of gliomas but deficiency of effective treatment and prevalent
chemoresistance have elicited interests in exploring and developing new agents. Paris …

Although new chemotherapy significantly increased the survival of breast cancer (BC)
patients, the use of these drugs is often associated with serious toxicity. The discovery of …

Paris polyphylla. is a traditional medicinal herb that has long been used to prevent cancer in
many Asian countries. Polyphyllin I (PPI), an important bioactive constituent of Paris …