Congenital adrenal hyperplasia—current insights in pathophysiology, diagnostics, and management

HL Claahsen-van der Grinten, PW Speiser… - Endocrine …, 2022 - academic.oup.com
Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders affecting
cortisol biosynthesis. Reduced activity of an enzyme required for cortisol production leads to …

Management challenges and therapeutic advances in congenital adrenal hyperplasia

A Mallappa, DP Merke - Nature Reviews Endocrinology, 2022 - nature.com
Abstract Treatment for congenital adrenal hyperplasia (CAH) was introduced in the 1950s
following the discovery of the structure and function of adrenocortical hormones. Although …

Adrenal insufficiency

S Hahner, RJ Ross, W Arlt, I Bancos… - Nature Reviews …, 2021 - nature.com
Adrenal insufficiency (AI) is a condition characterized by an absolute or relative deficiency of
adrenal cortisol production. Primary AI (PAI) is rare and is caused by direct adrenal failure …

Congenital adrenal hyperplasia due to steroid 21-hydroxylase deficiency: an endocrine society clinical practice guideline

PW Speiser, W Arlt, RJ Auchus… - The Journal of …, 2018 - academic.oup.com
Objective To update the congenital adrenal hyperplasia due to steroid 21-hydroxylase
deficiency clinical practice guideline published by the Endocrine Society in 2010 …

Adrenal crisis

RL Rushworth, DJ Torpy… - New England Journal of …, 2019 - Mass Medical Soc
Adrenal Crisis | New England Journal of Medicine Skip to main content The New England
Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES Cardiology …

Phase 3 Trial of Crinecerfont in Adult Congenital Adrenal Hyperplasia

RJ Auchus, O Hamidi, R Pivonello… - … England Journal of …, 2024 - Mass Medical Soc
Background Adrenal insufficiency in patients with classic 21-hydroxylase deficiency
congenital adrenal hyperplasia (CAH) is treated with glucocorticoid replacement therapy …

Congenital adrenal hyperplasia due to 21-hydroxylase deficiency

DP Merke, RJ Auchus - New England Journal of Medicine, 2020 - Mass Medical Soc
CAH Due to 21-Hydroxylase Deficiency Congenital adrenal hyperplasia, a common
autosomal recessive disorder, is potentially life-threatening in its classic form and may be …

Management of endocrine disease: diagnosis and management of the patient with non-classic CAH due to 21-hydroxylase deficiency

A Nordenström, H Falhammar - European journal of …, 2019 - academic.oup.com
Non-classic congenital adrenal hyperplasia (NCAH) is a relatively common disorder
regardless of ethnicity, but most cases are never diagnosed, especially in males. A baseline …

The impact of SARS-Cov-2 virus infection on the endocrine system

NP Somasundaram, I Ranathunga… - Journal of the …, 2020 - academic.oup.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus has spread across
the globe rapidly causing an unprecedented pandemic. Because of the novelty of the …

Adrenal crisis: prevention and management in adult patients

R Dineen, CJ Thompson… - Therapeutic advances in …, 2019 - journals.sagepub.com
Adrenal crisis is an acute life-threatening emergency contributing to the excess mortality that
is reported in patients with adrenal insufficiency. The incidence of adrenal crisis is estimated …