Human cancers share properties referred to as hallmarks, among which sustained
proliferation, escape from apoptosis, and genomic instability are the most pervasive. The …

Abstract Poly (ADP-ribose) polymerase (PARP) inhibitors and platinum-based
chemotherapies have been found to be particularly effective in tumors that harbor …

The molecular landscape in non-muscle-invasive bladder cancer (NMIBC) is characterized
by large biological heterogeneity with variable clinical outcomes. Here, we perform an …

Background Disease surveillance in patients with bladder cancer is important for early
diagnosis of progression and metastasis and for optimised treatment. Objective To develop …

Chromosomal instability (CIN), a feature of most adult neoplasms from their early stages
onward, is a driver of tumorigenesis. However, several malignancy subtypes, including …

Oncogene-induced replication stress (RS) promotes cancer development but also impedes
tumor growth by activating anti-cancer barriers. To determine how cancer cells adapt to RS …

Cancer genomes exhibit numerous deletions, some of which inactivate tumor suppressor
genes and/or correspond to unstable genomic regions, notably common fragile sites (CFSs) …

Background Ki-67 is an established marker of cell proliferation, and the Ki-67 index
correlates with the clinical course of several cancer types, including bladder cancer (BC) …

TIMELESS (TIM) is a mammalian homolog of a Drosophila circadian rhythm gene, but its
circadian properties in mammals have yet to be determined. TIM appears to be essential for …

Accurate replication of the genome is fundamental to cellular survival and tumor prevention.
The DNA replication fork is vulnerable to DNA lesions and damages that impair replisome …