TTD: Therapeutic Target Database describing target druggability information
Y Zhou, Y Zhang, D Zhao, X Yu, X Shen… - Nucleic acids …, 2024 - academic.oup.com
Target discovery is one of the essential steps in modern drug development, and the
identification of promising targets is fundamental for developing first-in-class drug. A variety …
identification of promising targets is fundamental for developing first-in-class drug. A variety …
[HTML][HTML] Sex/gender-related differences in inflammaging
F Olivieri, F Marchegiani, G Matacchione… - Mechanisms of ageing …, 2023 - Elsevier
Geroscience puts mechanisms of aging as a driver of the most common age-related
diseases and dysfunctions. Under this perspective, addressing the basic mechanisms of …
diseases and dysfunctions. Under this perspective, addressing the basic mechanisms of …
[HTML][HTML] Nicotinic acetylcholine receptors and learning and memory deficits in Neuroinflammatory diseases
Animal survival depends on cognitive abilities such as learning and memory to adapt to
environmental changes. Memory functions require an enhanced activity and connectivity of …
environmental changes. Memory functions require an enhanced activity and connectivity of …
Lipidome‐and genome‐wide study to understand sex differences in circulatory lipids
R Tabassum, S Ruotsalainen… - Journal of the …, 2022 - Am Heart Assoc
Background Despite well‐recognized differences in the atherosclerotic cardiovascular
disease risk between men and women, sex differences in risk factors and sex‐specific …
disease risk between men and women, sex differences in risk factors and sex‐specific …
Rare variants in long non-coding RNAs are associated with blood lipid levels in the TOPMed whole-genome sequencing study
Long non-coding RNAs (lncRNAs) are known to perform important regulatory functions in
lipid metabolism. Large-scale whole-genome sequencing (WGS) studies and new statistical …
lipid metabolism. Large-scale whole-genome sequencing (WGS) studies and new statistical …
Genetic Association of Lipids and Lipid-Lowering Drug Target Genes With Attention Deficit Hyperactivity Disorder
D Guo, W Sheng, Y Cai, J Shu… - Journal of Attention …, 2024 - journals.sagepub.com
Background: Lipid metabolism plays an essential role in nervous system development.
Cholesterol deficiency leads to a variety of neurodevelopmental disorders, such as autism …
Cholesterol deficiency leads to a variety of neurodevelopmental disorders, such as autism …
[HTML][HTML] Comparison of methods utilizing sex-specific PRSs derived from GWAS summary statistics
The polygenic risk score (PRS) is calculated as the weighted sum of an individual's
genotypes and their estimated effect sizes, which is often used to estimate an individual's …
genotypes and their estimated effect sizes, which is often used to estimate an individual's …
[HTML][HTML] Effect of biological sex on human circulating lipidome: An overview of the literature
R Tabassum, E Widén, S Ripatti - Atherosclerosis, 2023 - Elsevier
Cardiovascular diseases (CVD) are the leading cause of death worldwide for both men and
women, but their prevalence and burden show marked sex differences. The existing …
women, but their prevalence and burden show marked sex differences. The existing …
Causal effects of circulating lipids and lipid-lowering drugs on the risk of urinary stones: a Mendelian randomization study
Z Tan, J Hong, A Sun, M Ding, J Shen - Frontiers in Endocrinology, 2023 - frontiersin.org
Background Previous studies have yielded conflicting findings regarding the association
between circulating lipids and lipid-lowering drugs with urinary stones, and the causal …
between circulating lipids and lipid-lowering drugs with urinary stones, and the causal …
BMI at different childhood age periods associated with cardiometabolic disorders in young adulthood
Y Qian, Y Kong, N Wan, Y Yan - Obesity, 2023 - Wiley Online Library
Objective The aim of this study was to investigate when the association between childhood
obesity and adult cardiometabolic disorders starts to be operative. Methods The study cohort …
obesity and adult cardiometabolic disorders starts to be operative. Methods The study cohort …