[PDF][PDF] The pathobiology of vascular dementia

C Iadecola - Neuron, 2013 - cell.com
Vascular cognitive impairment defines alterations in cognition, ranging from subtle deficits to
full-blown dementia, attributable to cerebrovascular causes. Often coexisting with …

[HTML][HTML] Challenges and strategies for in situ endothelialization and long-term lumen patency of vascular grafts

Y Zhuang, C Zhang, M Cheng, J Huang, Q Liu… - Bioactive Materials, 2021 - Elsevier
Vascular diseases are the most prevalent cause of ischemic necrosis of tissue and organ,
which even result in dysfunction and death. Vascular regeneration or artificial vascular graft …

Critical reevaluation of endothelial progenitor cell phenotypes for therapeutic and diagnostic use

GP Fadini, D Losordo, S Dimmeler - Circulation research, 2012 - Am Heart Assoc
Diverse subsets of endothelial progenitor cells (EPCs) are used for the treatment of ischemic
diseases in clinical trials, and circulating EPCs levels are considered as biomarkers for …

Concise review: circulating endothelial progenitor cells for vascular medicine

T Asahara, A Kawamoto, H Masuda - Stem cells, 2011 - academic.oup.com
Endothelial progenitor cells (EPCs) have been isolated and shown to be effective in animal
models of ischemia, and many groups involved in clinical trials have demonstrated that EPC …

[PDF][PDF] Adenylyl cyclase-associated protein 1 is a receptor for human resistin and mediates inflammatory actions of human monocytes

S Lee, HC Lee, YW Kwon, SE Lee, Y Cho, J Kim, S Lee… - Cell metabolism, 2014 - cell.com
Human resistin is a cytokine that induces low-grade inflammation by stimulating monocytes.
Resistin-mediated chronic inflammation can lead to obesity, atherosclerosis, and other …

[HTML][HTML] Heart failure with preserved ejection fraction: a review of cardiac and noncardiac pathophysiology

AB Gevaert, JRA Boen, VF Segers… - Frontiers in …, 2019 - frontiersin.org
Heart failure with preserved ejection fraction (HFpEF) is one of the largest unmet clinical
needs in 21st-century cardiology. It is a complex disorder resulting from the influence of …

Postischemic revascularization: from cellular and molecular mechanisms to clinical applications

JS Silvestre, DM Smadja, BI Levy - Physiological reviews, 2013 - journals.physiology.org
After the onset of ischemia, cardiac or skeletal muscle undergoes a continuum of molecular,
cellular, and extracellular responses that determine the function and the remodeling of the …

Vascular repair by endothelial progenitor cells

A Zampetaki, JP Kirton, Q Xu - Cardiovascular research, 2008 - academic.oup.com
Accumulating evidence indicates the impact of endothelial progenitor cells (EPCs) in
vascular repair. In patients, the number of EPCs is negatively correlated with the severity of …

Granzymes: the molecular executors of immune-mediated cytotoxicity

ZLZ Hay, JE Slansky - International Journal of Molecular Sciences, 2022 - mdpi.com
Cytotoxic T lymphocytes, differentiated CD8+ T cells, use multiple mechanisms to mediate
their function, including release of granules containing perforin and granzymes at target …

Downregulation of microRNA-126 in endothelial progenitor cells from diabetes patients, impairs their functional properties, via target gene Spred-1

S Meng, JT Cao, B Zhang, Q Zhou, CX Shen… - Journal of molecular and …, 2012 - Elsevier
Diabetes mellitus (DM) adversely affects the number and function of circulating endothelial
progenitor cells (EPCs). Consequently, there is also a reduction in the repair mechanism of …