Design, evaluation and structure—Activity relationship studies of the AChE reactivators against organophosphorus pesticides
Organophosphate pesticides (OPPs; eg chlorpyrifos, diazinon, paraoxon) are a wide and
heterogeneous group of organophosphorus compounds. Their biological activity of …
heterogeneous group of organophosphorus compounds. Their biological activity of …
Trends in the recent patent literature on cholinesterase reactivators (2016–2019)
Acetylcholinesterase (AChE) is the key enzyme responsible for deactivating the ACh
neurotransmitter. Irreversible or prolonged inhibition of AChE, therefore, elevates synaptic …
neurotransmitter. Irreversible or prolonged inhibition of AChE, therefore, elevates synaptic …
Pyridinium Oximes with Ortho-Positioned Chlorine Moiety Exhibit Improved Physicochemical Properties and Efficient Reactivation of Human Acetylcholinesterase …
T Zorbaz, D Malinak, N Maraković… - Journal of medicinal …, 2018 - ACS Publications
Six chlorinated bispyridinium mono-oximes, analogous to potent charged reactivators K027,
K048, and K203, were synthesized with the aim of improving lipophilicity and reducing the p …
K048, and K203, were synthesized with the aim of improving lipophilicity and reducing the p …
Activation of (un) regulated cell death as a new perspective for bispyridinium and imidazolium oximes
Oximes, investigated as antidotes against organophosphates (OP) poisoning, are known to
display toxic effects on a cellular level, which could be explained beyond action on …
display toxic effects on a cellular level, which could be explained beyond action on …
Investigation of the reactivation kinetics of a large series of bispyridinium oximes with organophosphate-inhibited human acetylcholinesterase
The limited effectiveness of the established oximes obidoxime and pralidoxime resulted in
ongoing research on novel oximes for the reactivation of acetylcholinesterase (AChE) …
ongoing research on novel oximes for the reactivation of acetylcholinesterase (AChE) …
An evaluation of therapeutic and reactivating effects of newly developed oximes (K156, K203) and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun …
The potency of newly developed monoxime bispyridinium compounds (K156, K203) in
reactivating tabun-inhibited acetylcholinesterase and reducing tabun-induced lethal toxic …
reactivating tabun-inhibited acetylcholinesterase and reducing tabun-induced lethal toxic …
Molecular modeling and in vitro reactivation study between the oxime BI-6 and acetylcholinesterase inhibited by different nerve agents
JOS Giacoppo, T CC França, K Kuča… - Journal of …, 2015 - Taylor & Francis
Nerve agents are organophosphates acting as potent inhibitors of acetylcholinesterase
(AChE), the enzyme responsible for the hydrolysis of acetylcholine and, consequently, the …
(AChE), the enzyme responsible for the hydrolysis of acetylcholine and, consequently, the …
Chlorpyrifos removal in an artificially contaminated soil using novel bacterial strains and cyclodextrin. Evaluation of its effectiveness by ecotoxicity studies
The removal of chlorpyrifos (CLP) from the environment is a matter of general interest,
because it is one of the most widely used insecticides in the world but presents a high …
because it is one of the most widely used insecticides in the world but presents a high …
Mono-oxime bisquaternary acetylcholinesterase reactivators with prop-1, 3-diyl linkage—Preparation, in vitro screening and molecular docking
The treatment of organophosphorus (OP) poisoning consists of the administration of a
parasympatholytic agent (eg, atropine), an anticonvulsant (eg, diazepam) and an …
parasympatholytic agent (eg, atropine), an anticonvulsant (eg, diazepam) and an …
Reactivation kinetics of 31 structurally different bispyridinium oximes with organophosphate-inhibited human butyrylcholinesterase
Organophosphorus compounds (OP) are bound to human butyrylcholinesterase (BChE) and
endogenous or exogenous BChE may act as a stoichiometric scavenger. Adequate amounts …
endogenous or exogenous BChE may act as a stoichiometric scavenger. Adequate amounts …