Tumour growth is accompanied by tumour evasion of the immune system, a process that is
facilitated by immune checkpoint molecules such as programmed cell death protein 1 (PD1) …

Fucosylated carbohydrate structures are involved in a variety of biological and pathological
processes in eukaryotic organisms including tissue development, angiogenesis, fertilization …

How disseminated tumour cells engage specific stromal components in distant organs for
survival and outgrowth is a critical but poorly understood step of the metastatic cascade …

Human milk oligosaccharides, representing the third largest fraction of human milk, have
been assigned important protective functions for newborns acting as bifidogenic substrates …

The oligosaccharide chains (glycans) attached to cell surface and extracellular proteins and
lipids are known to mediate many important biological roles. However, for many glycans …

The laboratory rat has been used as a surrogate to study human biology for more than a
century. Here we present the first genome-scale network reconstruction of Rattus norvegicus …

This chapter provides historical background to the field of glycobiology and an overview of
this book. General terms found throughout the volume are also considered. The common …

IgG1 antibodies produced in Chinese hamster ovary (CHO) cells are heavily α1, 6‐
fucosylated, a modification that reduces antibody‐dependent cellular cytotoxicity (ADCC) …

GDP-L-Fuc: N-acetyl-β-D-glucosaminide α1-6-fucosyltransferase (α1-6FucT) catalyzes the
transfer of fucose from GDP-Fuc to N-linked type complex glycoproteins. This enzyme was …

Abstract α3-fucosyltransferases (α3-FucTs) catalyze the final step in the synthesis of a range
of important glycoconjugates that function in cell adhesion and lymphocyte recirculation. Six …