A low protein maternal diet during gestation has negative effects on male fertility markers in rats–A Systematic Review and Meta‐analysis

PK Ajuogu, MAK Al‐Aqbi, RA Hart… - Journal of Animal …, 2021 - Wiley Online Library
Research indicates that some adult diseases including reproductive pathologies are
programmed in utero during foetal development. In particular, maternal low dietary protein …

miR-18a-5p is involved in the developmental origin of prostate cancer in maternally malnourished offspring rats: A DOHaD approach

SAA Santos, LMF Portela, ACL Camargo… - International Journal of …, 2022 - mdpi.com
The Developmental Origins of Health and Disease (DOHaD) concept correlates early life
exposure to stressor conditions with the increased incidence of non-communicable chronic …

Maternal protein malnutrition: effects on prostate development and adult disease

JC Rinaldi, SAA Santos, KT Colombelli… - … origins of health and …, 2018 - cambridge.org
Well-controlled intrauterine development is an essential condition for many aspects of
normal adult physiology and health. This process is disrupted by poor maternal nutrition …

Maternal low-protein diet impairs prostate growth in young rat offspring and induces prostate carcinogenesis with aging

SAA Santos, AC Camargo… - The Journals of …, 2019 - academic.oup.com
Carcinogenesis is frequently linked to genetic background, however, exposure to
environmental risk factors has gained attention as the etiologic agent for several types of …

Impairment of microvascular angiogenesis is associated with delay in prostatic development in rat offspring of maternal protein malnutrition

KT Colombelli, SAA Santos, ACL Camargo… - General and …, 2017 - Elsevier
Experimental data demonstrated the negative impact of maternal protein malnutrition (MPM)
on rat prostate development, but the mechanism behind the impairment of prostate growth …

[HTML][HTML] Fourier transform infrared (FT-IR) study on cyanide induced biochemical and structural changes in rat sperm

SM Shivanoor, M David - Toxicology Reports, 2015 - Elsevier
In the recent years, great attention had been focused on cyanide toxicity because of its
widespread use in industries and considered to be a ubiquitous pollutant in the …

[HTML][HTML] Developmental priming of cancer susceptibility

I Panzeri, L Fagnocchi, S Apostle, M Tompkins… - bioRxiv, 2023 - ncbi.nlm.nih.gov
SUMMARY DNA mutations are necessary drivers of cancer, yet only a small subset of
mutated cells go on to cause the disease. To date, the mechanisms that determine which …

Maternal malnutrition associated with postnatal sugar consumption increases inflammatory response and prostate disorders in rat offspring

MN Fioretto, KT Colombelli, CLF da Silva… - Molecular and Cellular …, 2024 - Elsevier
Maternal malnutrition can alter developmental biology, programming health and disease in
offspring. The increase in sugar consumption during the peripubertal period, a worldwide …

Gestational protein restriction delays prostate morphogenesis in male rats

CF Pinho, MA Ribeiro, JC Rinaldi… - Reproduction …, 2014 - CSIRO Publishing
Maternal malnutrition due to a low-protein diet is associated with functional disorders in
adulthood, which may be related to embryonic development failures. The effects of …

[HTML][HTML] Targeting Wistar rat as a model for studying benign, premalignant and malignant lesions of the prostate

GH Campolina-Silva, H Werneck-Gomes, BT Maria… - Life sciences, 2020 - Elsevier
Aims The purpose of this study was to describe a suitable experimental model for studying
aging-related prostate disorders including cancer. Materials and methods 12-month old …