Abstract Coronavirus disease 2019 (COVID-19), a highly infectious disease caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected more than …

Animal viruses are parasites of animal cells that have characteristics such as heredity and
replication. Viruses can be divided into non-enveloped and enveloped viruses if a lipid …

The Spike protein of SARS-CoV-2, its receptor-binding domain (RBD), and its primary
receptor ACE2 are extensively glycosylated. The impact of this post-translational …

Most enveloped viruses rely on the host cell endoplasmic reticulum (ER) quality control (QC)
machinery for proper folding of glycoproteins. The key ER α-glucosidases (α-Glu) I and II of …

Background Despite clinical success with anti-spike vaccines, the effectiveness of
neutralizing antibodies and vaccines has been compromised by rapidly spreading SARS …

In this era, broad‐spectrum prodrugs with anti‐severe acute respiratory syndrome
coronavirus 2 (SARS‐CoV‐2) activities are gaining considerable attention owing to their …

The severity of SARS-CoV-2 infection is highly variable and yet the molecular basis for this
effect remains elusive. One potential contribution are differences in the glycosylation of …

Nicotiana benthamiana is used worldwide as production host for recombinant proteins.
Many recombinant proteins such as monoclonal antibodies, growth factors or viral antigens …

Viruses are intracellular parasites that subvert the functions of their host cells to accomplish
their infection cycle. The endoplasmic reticulum (ER)-residing chaperone proteins are …

Functional and epidemiological data suggest that N-linked glycans on the SARS-CoV-2
Spike protein may contribute to viral infectivity. To investigate this, we created a panel of N-to …