The interferons (IFNs) were originally described over 50 years ago, identified by their ability
to confer viral resistance to cells. We now know that they are much more than just anti‐viral …

Abstract Type I interferons (IFN-Is) are a group of molecules with pleiotropic effects on the
immune system forming a crucial link between innate and adaptive immune responses …

Many successful vaccines induce persistent antibody responses that can last a lifetime. The
mechanisms by which they do so remain unclear, but emerging evidence indicates that they …

Type I interferons (IFNs) are a family of cytokines involved in the defense against viral
infections that play a key role in the activation of both the innate and adaptive immune …

Abstract T and B lymphocytes (T and B cells) are immune effector cells that play critical roles
in adaptive immunity and defend against external pathogens in most vertebrates, including …

Germinal centers (GCs) are dynamic microenvironments that form in the secondary
lymphoid organs and generate somatically mutated high-affinity antibodies necessary to …

Perturbations in immune processes are a hallmark of a number of autoimmune and
inflammatory disorders. Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is …

Impaired wound healing is a serious complication of diabetes that negatively affects the
patient's socioeconomic life. Multiple mechanisms contribute to impaired diabetic wound …

Pulmonary hypertension (PH) is a cardiovascular disease caused by extensive vascular
remodeling in the lungs, which ultimately leads to death in consequence of right ventricle …

A hallmark of systemic lupus erythematosus (SLE) is the breaking of B-cell tolerance with the
generation of high-affinity autoantibodies; however, the antibody-independent features of …