Low back pain is a major public health concern experienced by 80% of the world's
population during their lifetime, which is closely associated with intervertebral disc (IVD) …

Intervertebral disc (IVD) is an avascular tissue which contributes to the weight bearing,
motion, and flexibility of spine. However, IVD is susceptible to damage and even failure due …

Annulus fibrosus (AF) tissue engineering has attracted increasing attention as a promising
therapy for degenerative disc disease (DDD). However, regeneration of AF still faces many …

Abstract Development of mesenchymal stem cell-based tissue engineered implantable
devices requires prolonged in vitro culture for the development of a three-dimensional …

Intervertebral disc degeneration is a disease of the discs connecting adjoining vertebrae in
which structural damage leads to loss of disc integrity. Degeneration of the disc can be a …

The intervertebral disc (IVD) is an integral load-bearing tissue that derives its function from
its composite structure and extracellular matrix composition. IVD herniations involve the …

Degenerative disc degeneration (DDD) is the major cause of low back pain, which seriously
affects the life of patients. Current surgical and conservative treatments only relieve the pain …

The spatiotemporal interaction and constant iterative feedback between fibroblasts,
extracellular matrix, and environmental cues are central for investigating the fibroblast …

Chronic low back pain has both substantial social and economic impacts on patients and
healthcare budgets. Adding to the magnitude of the problem is the difficulty in identifying the …

Mechano-rehabilitation, also known as mechanotherapy, represents the forefront of
noninvasive treatment for musculoskeletal (MSK) tissue disorders, encompassing conditions …