Glioblastoma (GBM) is one of the most aggressive and lethal human brain tumors. At
present, GBMs are divided in primary and secondary on the basis of the mutational status of …

Squamous cell carcinomas (SCCs) represent the most frequent human solid tumors and are
a major cause of cancer mortality. These highly heterogeneous tumors arise from closely …

Background Myeloid cells are an abundant leukocyte in many types of tumors and contribute
to immune evasion. Expression of the enzyme arginase 1 (Arg1) is a defining feature of …

Esophageal cancer is a deadly disease, ranking sixth among all cancers in mortality.
Despite incremental advances in diagnostics and therapeutics, esophageal cancer still …

Myeloid-derived suppressor cells (MDSCs) contribute to tumor-mediated immune escape
and negatively correlate with overall survival of cancer patients. Nowadays, a variety of …

Indoleamine 2, 3-dioxigenase 1 (IDO1) is the main enzyme that catalyzes the first, rate-
limiting step of the so-called “kynurenine pathway”, ie, the metabolic cascade that converts …

Immunotherapy has shown great promise in the fight against cancer, as evidenced by the
clinical efficacy of chimeric antigen receptor T cells in hematologic malignancies and …

Myeloid-derived suppressor cells (MDSC) are an immunosuppressive population of
immature myeloid cells found in advanced-stage cancer patients and mouse tumor models …

Oncolytic virotherapy relies on the administration of non-pathogenic viral strains that
selectively infect and kill malignant cells while favoring the elicitation of a therapeutically …

Myeloid-derived suppressor cells (MDSCs) comprise monocytic and granulocytic innate
immune cells with the capability of suppressing T-and NK-cell responses. While the role of …