Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment
H Yu, M Kortylewski, D Pardoll - Nature reviews immunology, 2007 - nature.com
Immune cells in the tumour microenvironment not only fail to mount an effective anti-tumour
immune response, but also interact intimately with the transformed cells to promote …
immune response, but also interact intimately with the transformed cells to promote …
Alcoholism: a systems approach from molecular physiology to addictive behavior
R Spanagel - Physiological reviews, 2009 - journals.physiology.org
Alcohol consumption is an integral part of daily life in many societies. The benefits
associated with the production, sale, and use of alcoholic beverages come at an enormous …
associated with the production, sale, and use of alcoholic beverages come at an enormous …
Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologue
Toxoplasma gondii, an obligate intracellular parasite of the phylum Apicomplexa, can cause
severe disease in humans with an immature or suppressed immune system. The outcome of …
severe disease in humans with an immature or suppressed immune system. The outcome of …
Matrix-insensitive protein assays push the limits of biosensors in medicine
Advances in biosensor technologies for in vitro diagnostics have the potential to transform
the practice of medicine. Despite considerable work in the biosensor field, there is still no …
the practice of medicine. Despite considerable work in the biosensor field, there is still no …
Notch signals positively regulate activity of the mTOR pathway in T-cell acute lymphoblastic leukemia
Constitutive Notch activation is required for the proliferation of a subgroup of T-cell acute
lymphoblastic leukemia (T-ALL). Downstream pathways that transmit pro-oncogenic signals …
lymphoblastic leukemia (T-ALL). Downstream pathways that transmit pro-oncogenic signals …
CD4+ CD25+ T regulatory cells, immunotherapy of cancer, and interleukin-2
PA Antony, NP Restifo - Journal of immunotherapy, 2005 - journals.lww.com
CD4+ CD25+ T regulatory (T reg) cells control immunologic tolerance to self-antigens and
play a role in suppressing antitumor immune responses, but the mechanism of suppression …
play a role in suppressing antitumor immune responses, but the mechanism of suppression …
Frequent PTEN genomic alterations and activated phosphatidylinositol 3-kinase pathway in basal-like breast cancer cells
B Marty, V Maire, E Gravier, G Rigaill… - Breast Cancer …, 2008 - Springer
Abstract Introduction Basal-like carcinomas (BLCs) and human epidermal growth factor
receptor 2 overexpressing (HER2+) carcinomas are the subgroups of breast cancers that …
receptor 2 overexpressing (HER2+) carcinomas are the subgroups of breast cancers that …
Phosphoprotein pathway mapping: Akt/mammalian target of rapamycin activation is negatively associated with childhood rhabdomyosarcoma survival
Mapping of protein signaling networks within tumors can identify new targets for therapy and
provide a means to stratify patients for individualized therapy. Despite advances in …
provide a means to stratify patients for individualized therapy. Despite advances in …
Toll-like receptor 2 and poly (ADP-ribose) polymerase 1 promote central nervous system neuroinflammation in progressive EAE
Multiple sclerosis is an inflammatory disease of the central nervous system that begins as a
relapsing-remitting disease (RRMS) and is followed by a progressive phase (SPMS). The …
relapsing-remitting disease (RRMS) and is followed by a progressive phase (SPMS). The …
Antibody arrays in cancer research
BB Haab - Molecular & cellular proteomics, 2005 - ASBMB
Antibody arrays have valuable applications in cancer research. Many different antibody
array technologies have been developed, each with particular advantages, disadvantages …
array technologies have been developed, each with particular advantages, disadvantages …