The discovery in 2006 that loss-of-function mutations in the filaggrin gene (FLG) cause
ichthyosis vulgaris and can predispose to atopic dermatitis (AD) galvanized the dermatology …

Skin barrier dysfunction caused by endogenous or exogenous factors can lead to various
disorders such as xerosis cutis, ichthyoses, and atopic dermatitis. Filaggrin is a pivotal …

Background Tight junctions (TJs) form a barrier on the apical side of neighboring epithelial
cells in the bronchial mucosa. Changes in their integrity might play a role in asthma …

Highlights•Inherited or acquired filaggrin deficiency plays an essential role in AD.•Increasing
knowledge has been gained about consequences of filaggrin deficiency.•Novel murine and …

Nicotinamide (NAM) is an amide form of vitamin B3 and the precursor of nicotinamide
adenine dinucleotide (NAD+), an essential co-enzyme of redox reactions for adenosine …

Aging is the most important risk factor for the development of major life-threatening diseases
such as cardiovascular disorders, cancer, and neurodegenerative disorders. The aging …

Macroautophagy (hereafter autophagy) is a cellular “self-eating” process that is implicated in
many human cancers, where it can act to either promote or suppress tumorigenesis …

Abstract Sirtuins (SIRT1-7) are NAD-dependent proteins with the enzymatic activity of
deacetylases and ADP ribosyltransferases. SIRT1 is the proto member of the proteins in the …

Atopic dermatitis (AD) is one of the most common chronic, inflammatory skin disorders with a
complex etiology and a broad spectrum of clinical phenotypes. Despite its high prevalence …

Pulmonary fibrosis is the leading cause of death in systemic sclerosis (SSc). Sirtuin1 (SIRT1)
is a deacetylase with known antiinflammatory and antifibrotic activity in the liver, kidney, and …