The risk assessment of chemical carcinogens is one major task in toxicology. Even though
exposure has been mitigated effectively during the last decades, low levels of carcinogenic …

Exposure to chemical agents is an inevitable consequence of modern society; some of these
agents are hazardous to human health. The effects of chemical carcinogens are of great …

Abstract The Scientific Committee reviewed the current state‐of‐the‐science on genotoxicity
testing and provided a commentary and recommendations on genotoxicity testing strategies …

Genetic toxicology data have traditionally been employed for qualitative, rather than
quantitative evaluations of hazard. As a continuation of our earlier report that analyzed ethyl …

Mutations induced in somatic cells and germ cells are responsible for a variety of human
diseases, and mutation per se has been considered an adverse health concern since the …

In experimental animals and humans, aflatoxin B1 (AFB1) is a potent hepatic toxin and
carcinogen. The synthetic oleanane triterpenoid 1-[2-cyano-3-, 12-dioxooleana-1, 9 (11) …

Isoeugenol has recently been evaluated as possibly carcinogenic (Group 2B) by the WHO
International Agency for Research on Cancer (IARC). In light of this evaluation, an updated …

Benzo [a] pyrene is a known human carcinogen. As underlying mechanism, the induction of
stable DNA adducts and mutations have been repeatedly demonstrated. Also, the activation …

Dioxane is a widely used synthetic industrial chemical and its contamination of drinking
water and food is a potential health concern. It induces liver tumors when administered in …

We evaluated levels of neuronal DNA damage after acute or repeated cocaine treatment in
different brain areas of female rats after ovariectomy or sham surgery. Rats in the control and …