Alzheimer's disease (AD) is an irreversible, progressive neurodegenerative brain disorder
with no current cure. One of the important therapeutic approaches of AD is the inhibition of β …

Protein kinases (PKs) have been recognized as central nervous system (CNS)-disease-
relevant targets due to their master regulatory role in different signal transduction cascades …

The past decade has brought tremendous progress in unraveling the pathophysiology of
Alzheimer's disease (AD). While increasingly sophisticated immunotherapy targeting soluble …

Fyn is a non-receptor or cytoplasmatic tyrosine kinase (TK) belonging to the Src family
kinases (SFKs) involved in multiple transduction pathways in the central nervous system …

Fyn is a non-receptor tyrosine kinase that belongs to the Src family kinases (SFKs) which
under normal physiological conditions is involved in signal transduction pathways in the …

1. INTRODUCTION Nitrogen-containing heterocycles are widely distributed in nature and
essential for life, playing a vital role in the metabolism of all living cells. Among the many …

Objective Pregnancy is accompanied by dramatic physiological changes in maternal plasma
proteins. Characterization of the maternal plasma proteome in normal pregnancy is an …

Midkine (MK) and pleiotrophin (PTN) are two neurotrophic factors that are highly up‐
regulated in different brain regions after the administration of various drugs of abuse and in …

Cancer metabolic plasticity, including changes in fatty acid metabolism utilisation, is now
widely appreciated as a key driver for cancer cell growth, survival and malignancy. Hence …

Kinases are ubiquitous enzymes involved in the regulation of critical cellular pathways.
However, in silico modelling of the conformational ensembles of these enzymes is difficult …