Translation in prokaryotes
MV Rodnina - Cold Spring Harbor perspectives in …, 2018 - cshperspectives.cshlp.org
This review summarizes our current understanding of translation in prokaryotes, focusing on
the mechanistic and structural aspects of each phase of translation: initiation, elongation …
the mechanistic and structural aspects of each phase of translation: initiation, elongation …
T-2 toxin neurotoxicity: role of oxidative stress and mitochondrial dysfunction
Mycotoxins are highly diverse secondary metabolites produced in nature by a wide variety of
fungi. Mycotoxins cause animal feed and food contamination, resulting in mycotoxicosis. T-2 …
fungi. Mycotoxins cause animal feed and food contamination, resulting in mycotoxicosis. T-2 …
A proton wire to couple aminoacyl-tRNA accommodation and peptide-bond formation on the ribosome
YS Polikanov, TA Steitz, CA Innis - Nature structural & molecular …, 2014 - nature.com
During peptide-bond formation on the ribosome, the α-amine of an aminoacyl-tRNA attacks
the ester carbonyl carbon of a peptidyl-tRNA to yield a peptide lengthened by one amino …
the ester carbonyl carbon of a peptidyl-tRNA to yield a peptide lengthened by one amino …
Structural basis of the translational elongation cycle
RM Voorhees, V Ramakrishnan - Annual review of biochemistry, 2013 - annualreviews.org
The sequential addition of amino acids to a growing polypeptide chain is carried out by the
ribosome in a complicated multistep process called the elongation cycle. It involves accurate …
ribosome in a complicated multistep process called the elongation cycle. It involves accurate …
The RNA world hypothesis: the worst theory of the early evolution of life (except for all the others)a
HS Bernhardt - Biology direct, 2012 - Springer
The problems associated with the RNA world hypothesis are well known. In the following I
discuss some of these difficulties, some of the alternative hypotheses that have been …
discuss some of these difficulties, some of the alternative hypotheses that have been …
Insights into the ribosome function from the structures of non-arrested ribosome–nascent chain complexes
During protein synthesis, the growing polypeptide threads through the ribosomal exit tunnel
and modulates ribosomal activity by itself or by sensing various small molecules, such as …
and modulates ribosomal activity by itself or by sensing various small molecules, such as …
In situ observation of peptide bond formation at the water–air interface
EC Griffith, V Vaida - … of the National Academy of Sciences, 2012 - National Acad Sciences
We report unambiguous spectroscopic evidence of peptide bond formation at the air–water
interface, yielding a possible mechanism providing insight into the formation of modern …
interface, yielding a possible mechanism providing insight into the formation of modern …
Competing reaction mechanisms of peptide bond formation in water revealed by deep potential molecular dynamics and path sampling
The formation of an amide bond is an essential step in the synthesis of materials and drugs,
and in the assembly of amino acids to form peptides. The mechanism of this reaction has …
and in the assembly of amino acids to form peptides. The mechanism of this reaction has …
Amides in nature and biocatalysis
J Pitzer, K Steiner - Journal of biotechnology, 2016 - Elsevier
Amides are widespread in biologically active compounds with a broad range of applications
in biotechnology, agriculture and medicine. Therefore, as alternative to chemical synthesis …
in biotechnology, agriculture and medicine. Therefore, as alternative to chemical synthesis …
Human DNMT1 transition state structure
Q Du, Z Wang, VL Schramm - Proceedings of the National …, 2016 - National Acad Sciences
Human DNA methyltransferase 1 (DNMT1) maintains the epigenetic state of DNA by
replicating CpG methylation signatures from parent to daughter strands, producing heritable …
replicating CpG methylation signatures from parent to daughter strands, producing heritable …