The nematode Caenorhabditis elegans has emerged as an important animal model in
various fields including neurobiology, developmental biology, and genetics. Characteristics …

Despite the ubiquitous roles of lipids in biology, the detection of lipids has relied on invasive
techniques, population measurements, or nonspecific labeling. Such difficulties can be …

Optical imaging of the dynamics of living specimens involves tradeoffs between spatial
resolution, temporal resolution, and phototoxicity, made more difficult in three dimensions …

The C. elegans genome has been completely sequenced, and the developmental anatomy
of this model organism is described at single-cell resolution. Here we utilize strategies that …

Both poikilotherms and homeotherms live longer at lower body temperatures, highlighting a
general role of temperature reduction in lifespan extension. However, the underlying …

Microscopy, phenotyping and visual screens are frequently applied to model organisms in
combination with genetics. Although widely used, these techniques for multicellular …

Toxicity of aggregation-prone proteins is thought to play an important role in aging and age-
related neurological diseases like Parkinson and Alzheimer's diseases. Here, we identify …

To provide accurate biological hypotheses and elucidate global properties of cellular
networks, systematic identification of protein-protein interactions must meet high quality …

We report a suite of key microfluidic devices for complex high-throughput whole-animal
genetic and drug screens. We demonstrate a high-speed microfluidic sorter that can isolate …

The deregulation of microRNA (miRNA) is frequently associated with a variety of cancers,
including hepatocellular carcinoma (HCC). In this study, we identified 10 upregulated …