Multisystem physiological perspective of human frailty and its modulation by physical activity

JA Taylor, PL Greenhaff, DB Bartlett… - Physiological …, 2023 - journals.physiology.org
“Frailty” is a term used to refer to a state characterized by enhanced vulnerability to, and
impaired recovery from, stressors compared with a nonfrail state, which is increasingly …

Gait and cognition: Mapping the global and discrete relationships in ageing and neurodegenerative disease

R Morris, S Lord, J Bunce, D Burn… - … & Biobehavioral Reviews, 2016 - Elsevier
Recent research highlights the association of gait and cognition in older adults but a
stronger understanding is needed to discern coincident pathophysiology, patterns of …

Neuroimaging of mobility in aging: a targeted review

R Holtzer, N Epstein, JR Mahoney… - … Series A: Biomedical …, 2014 - academic.oup.com
Background. The relationship between mobility and cognition in aging is well established,
but the relationship between mobility and the structure and function of the aging brain is …

Aging causes a reorganization of cortical and spinal control of posture

S Papegaaij, W Taube, S Baudry, E Otten… - Frontiers in aging …, 2014 - frontiersin.org
Classical studies in animal preparations suggest a strong role for spinal control of posture. In
humans it is now established that the cerebral cortex contributes to postural control of …

Cognitive function and gait speed under normal and dual-task walking among older adults with mild cognitive impairment

T Doi, H Shimada, H Makizako, K Tsutsumimoto… - BMC neurology, 2014 - Springer
Background Gait ability and cognitive function are interrelated during both normal walking
(NW) and dual-task walking (DTW), and gait ability is thus adversely affected by cognitive …

[HTML][HTML] The neural correlates of discrete gait characteristics in ageing: a structured review

J Wilson, L Allcock, R Mc Ardle, JP Taylor… - Neuroscience & …, 2019 - Elsevier
Gait is complex, described by diverse characteristics underpinned by widespread central
nervous system networks including motor and cognitive functions. Despite this, neural …

Brain structural change and gait decline: a longitudinal population‐based study

ML Callisaya, R Beare, TG Phan… - Journal of the …, 2013 - Wiley Online Library
Objectives To investigate longitudinal associations between changes in brain structure and
gait decline. Design Longitudinal. Setting Population‐based Tasmanian Study of Cognition …

Longitudinal patterns of leukoaraiosis and brain atrophy in symptomatic small vessel disease

C Lambert, P Benjamin, E Zeestraten, AJ Lawrence… - Brain, 2016 - academic.oup.com
Cerebral small vessel disease is a common condition associated with lacunar stroke,
cognitive impairment and significant functional morbidity. White matter hyperintensities and …

Slowing gait speed precedes cognitive decline by several years

T Skillbäck, K Blennow, H Zetterberg… - Alzheimer's & …, 2022 - Wiley Online Library
Introduction In this longitudinal study, we aimed to examine if slowing gait speed preceded
cognitive decline and correlated with brain amyloidosis. Methods The sample (n= 287) was …

[HTML][HTML] Cognition and gait show a distinct pattern of association in the general population

VJA Verlinden, JN van der Geest, A Hofman… - Alzheimer's & …, 2014 - Elsevier
Background With brain aging, cognition and gait deteriorate in several domains. However,
the interrelationship between cognitive and gait domains remains unclear. We investigated …