Relevance of multi-omics studies in cardiovascular diseases
P Leon-Mimila, J Wang… - Frontiers in cardiovascular …, 2019 - frontiersin.org
Cardiovascular diseases are the leading cause of death around the world. Despite the
larger number of genes and loci identified, the precise mechanisms by which these genes …
larger number of genes and loci identified, the precise mechanisms by which these genes …
ADAMTS proteases in cardiovascular physiology and disease
S Santamaria, R de Groot - Open biology, 2020 - royalsocietypublishing.org
The a disintegrin-like and metalloproteinase with thrombospondin motif (ADAMTS) family
comprises 19 proteases that regulate the structure and function of extracellular proteins in …
comprises 19 proteases that regulate the structure and function of extracellular proteins in …
Targeting gut microbiota–derived kynurenine to predict and protect the remodeling of the pressure-overloaded young heart
B Shi, X Zhang, Z Song, Z Dai, K Luo, B Chen… - Science …, 2023 - science.org
Pressure-overloaded left ventricular remodeling in young population is progressive and
readily degenerate into heart failure. The aims of this study were to identify a plasma …
readily degenerate into heart failure. The aims of this study were to identify a plasma …
Glutamyl-prolyl-tRNA synthetase regulates proline-rich pro-fibrotic protein synthesis during cardiac fibrosis
Rationale: Increased protein synthesis of profibrotic genes is a common feature in cardiac
fibrosis and heart failure. Despite this observation, critical factors and molecular …
fibrosis and heart failure. Despite this observation, critical factors and molecular …
Type V collagen in scar tissue regulates the size of scar after heart injury
Scar tissue size following myocardial infarction is an independent predictor of
cardiovascular outcomes, yet little is known about factors regulating scar size. We …
cardiovascular outcomes, yet little is known about factors regulating scar size. We …
A Disintegrin and Metalloproteinase (ADAM) and ADAM with thrombospondin motifs (ADAMTS) family in vascular biology and disease
S Zhong, RA Khalil - Biochemical pharmacology, 2019 - Elsevier
Abstract A Disintegrin and Metalloproteinase (ADAM) is a family of proteolytic enzymes that
possess sheddase function and regulate shedding of membrane-bound proteins, growth …
possess sheddase function and regulate shedding of membrane-bound proteins, growth …
The potential of integrating human and mouse discovery platforms to advance our understanding of cardiometabolic diseases
Cardiometabolic diseases encompass a range of interrelated conditions that arise from
underlying metabolic perturbations precipitated by genetic, environmental, and lifestyle …
underlying metabolic perturbations precipitated by genetic, environmental, and lifestyle …
Topological arrangement of cardiac fibroblasts regulates cellular plasticity
Rationale: Cardiac fibroblasts do not form a syncytium but reside in the interstitium between
myocytes. This topological relationship between fibroblasts and myocytes is maintained …
myocytes. This topological relationship between fibroblasts and myocytes is maintained …
Cardiac micro-RNA and transcriptomic profile of a novel swine model of chronic kidney disease and left ventricular diastolic dysfunction
Chronic kidney disease (CKD) is an independent risk factor for the development of heart
failure, but the underlying mechanisms remain unknown. Using a novel translational swine …
failure, but the underlying mechanisms remain unknown. Using a novel translational swine …