Radiotherapy is one of the major cancer treatment strategies. Exposure to penetrating
radiation causes cellular stress, directly or indirectly, due to the generation of reactive …

Accumulating lines of experimental evidence have revealed that hypoxia‐inducible factors,
HIF‐1α and HIF‐2α, are key regulators of the adaptation of cancer‐and metastasis‐initiating …

Simple Summary Some regions of aggressive malignancies experience hypoxia due to
inadequate blood supply. Cancer cells adapting to hypoxic conditions somehow become …

Abstract The phosphatidylinositol-3-kinase/Akt and the mammalian target of rapamycin
(PI3K/Akt/mTOR) pathway is one of the most frequently activated signaling pathways in …

Prostate cancer (PCA) is the leading malignancy in men and the second leading cause of
cancer-related deaths. Hypoxia (low O 2 condition) is considered an early event in prostate …

Background: Nowadays, ionizing radiation is used for several applications in medicine,
industry, agriculture, and nuclear power generation. Besides the beneficial roles of ionizing …

Radiotherapy (RT) is one of the mainstay treatments for prostate cancer (PCa), a highly
prevalent neoplasm among males worldwide. About 30% of newly diagnosed PCa patients …

Cancer is one of the most challenging diseases to manage. A sizeable number of
researches are done each year to find better diagnostic and therapeutic strategies. At the …

Cancer cells in hypoxia usually make adaptive changes in cellular metabolism, such as
altered autophagy. This might be a cause of enhanced radioresistance in some types of …

Background Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), a
conserved transcript with 8000 nt, is highly associated with malignancy of numerous cancer …